Lactylation: a Passing Fad or the Future of Posttranslational Modification

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and disea...

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Detalles Bibliográficos
Autores principales: Xin, Qi, Wang, Hai, Li, Qinglin, Liu, Sinan, Qu, Kai, Liu, Chang, Zhang, Jingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197907/
https://www.ncbi.nlm.nih.gov/pubmed/35224683
http://dx.doi.org/10.1007/s10753-022-01637-w
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author Xin, Qi
Wang, Hai
Li, Qinglin
Liu, Sinan
Qu, Kai
Liu, Chang
Zhang, Jingyao
author_facet Xin, Qi
Wang, Hai
Li, Qinglin
Liu, Sinan
Qu, Kai
Liu, Chang
Zhang, Jingyao
author_sort Xin, Qi
collection PubMed
description Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
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spelling pubmed-91979072022-06-16 Lactylation: a Passing Fad or the Future of Posttranslational Modification Xin, Qi Wang, Hai Li, Qinglin Liu, Sinan Qu, Kai Liu, Chang Zhang, Jingyao Inflammation Review Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies. Springer US 2022-02-27 2022 /pmc/articles/PMC9197907/ /pubmed/35224683 http://dx.doi.org/10.1007/s10753-022-01637-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Xin, Qi
Wang, Hai
Li, Qinglin
Liu, Sinan
Qu, Kai
Liu, Chang
Zhang, Jingyao
Lactylation: a Passing Fad or the Future of Posttranslational Modification
title Lactylation: a Passing Fad or the Future of Posttranslational Modification
title_full Lactylation: a Passing Fad or the Future of Posttranslational Modification
title_fullStr Lactylation: a Passing Fad or the Future of Posttranslational Modification
title_full_unstemmed Lactylation: a Passing Fad or the Future of Posttranslational Modification
title_short Lactylation: a Passing Fad or the Future of Posttranslational Modification
title_sort lactylation: a passing fad or the future of posttranslational modification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197907/
https://www.ncbi.nlm.nih.gov/pubmed/35224683
http://dx.doi.org/10.1007/s10753-022-01637-w
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