Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation

TGF-β is essential for inducing systemic tumor immunosuppression; thus, blocking TGF-β can greatly enhance antitumor immunity. However, there are still no effective TGF-β inhibitors in clinical use. Here, we show that the clinically approved compound ursodeoxycholic acid (UDCA), by degrading TGF-β,...

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Detalles Bibliográficos
Autores principales: Shen, Yingying, Lu, Chaojie, Song, Zhengbo, Qiao, Chenxiao, Wang, Jiaoli, Chen, Jinbiao, Zhang, Chengyan, Zeng, Xianchang, Ma, Zeyu, Chen, Tao, Li, Xu, Lin, Aifu, Guo, Jufeng, Wang, Jianli, Cai, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198048/
https://www.ncbi.nlm.nih.gov/pubmed/35701426
http://dx.doi.org/10.1038/s41467-022-31141-6

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