SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish

Precise genetic modifications in model organisms are essential for biomedical research. The recent development of PAM-less base editors makes it possible to assess the functional impact and pathogenicity of nucleotide mutations in animals. Here we first optimize SpG and SpRY systems in zebrafish by...

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Detalles Bibliográficos
Autores principales: Liang, Fang, Zhang, Yu, Li, Lin, Yang, Yexin, Fei, Ji-Feng, Liu, Yanmei, Qin, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198057/
https://www.ncbi.nlm.nih.gov/pubmed/35701400
http://dx.doi.org/10.1038/s41467-022-31034-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198057/
https://www.ncbi.nlm.nih.gov/pubmed/35701400
http://dx.doi.org/10.1038/s41467-022-31034-8

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