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High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography
HIGHLIGHTS: Polyimide-based flexible microneedle array (PI-MNA) electrodes realize high electrical/mechanical performance and are compatible with wearable wireless recording systems. The normalized electrode–skin interface impedance (EII) of the PI-MNA electrodes reaches 0.98 kΩ cm(2) at 1 kHz and 1...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198145/ https://www.ncbi.nlm.nih.gov/pubmed/35699782 http://dx.doi.org/10.1007/s40820-022-00870-0 |
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author | Li, Junshi Ma, Yundong Huang, Dong Wang, Zhongyan Zhang, Zhitong Ren, Yingjie Hong, Mengyue Chen, Yufeng Li, Tingyu Shi, Xiaoyi Cao, Lu Zhang, Jiayan Jiao, Bingli Liu, Junhua Sun, Hongqiang Li, Zhihong |
author_facet | Li, Junshi Ma, Yundong Huang, Dong Wang, Zhongyan Zhang, Zhitong Ren, Yingjie Hong, Mengyue Chen, Yufeng Li, Tingyu Shi, Xiaoyi Cao, Lu Zhang, Jiayan Jiao, Bingli Liu, Junhua Sun, Hongqiang Li, Zhihong |
author_sort | Li, Junshi |
collection | PubMed |
description | HIGHLIGHTS: Polyimide-based flexible microneedle array (PI-MNA) electrodes realize high electrical/mechanical performance and are compatible with wearable wireless recording systems. The normalized electrode–skin interface impedance (EII) of the PI-MNA electrodes reaches 0.98 kΩ cm(2) at 1 kHz and 1.50 kΩ cm(2) at 10 Hz, approximately 1/250 of clinical standard electrodes. This is the first report on the clinical study of microneedle electrodes. The PI-MNA electrodes are applied to clinical long-term continuous monitoring for polysomnography. ABSTRACT: Microneedle array (MNA) electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications. Existing schemes are limited by flexibility, biosafety, and manufacturing costs, which create large barriers for wider applications. Here, we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface, robustness of microneedles to penetrate the skin without fracture, and a simplified process to allow mass production. The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording. The normalized electrode–skin contact impedance reaches 0.98 kΩ cm(2) at 1 kHz and 1.50 kΩ cm(2) at 10 Hz, a record low value compared to previous reports and approximately 1/250 of the standard electrodes. The morphology, biosafety, and electrical/mechanical properties are fully characterized, and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized. The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording (over 8 h per night), providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00870-0. |
format | Online Article Text |
id | pubmed-9198145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-91981452022-06-16 High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography Li, Junshi Ma, Yundong Huang, Dong Wang, Zhongyan Zhang, Zhitong Ren, Yingjie Hong, Mengyue Chen, Yufeng Li, Tingyu Shi, Xiaoyi Cao, Lu Zhang, Jiayan Jiao, Bingli Liu, Junhua Sun, Hongqiang Li, Zhihong Nanomicro Lett Article HIGHLIGHTS: Polyimide-based flexible microneedle array (PI-MNA) electrodes realize high electrical/mechanical performance and are compatible with wearable wireless recording systems. The normalized electrode–skin interface impedance (EII) of the PI-MNA electrodes reaches 0.98 kΩ cm(2) at 1 kHz and 1.50 kΩ cm(2) at 10 Hz, approximately 1/250 of clinical standard electrodes. This is the first report on the clinical study of microneedle electrodes. The PI-MNA electrodes are applied to clinical long-term continuous monitoring for polysomnography. ABSTRACT: Microneedle array (MNA) electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications. Existing schemes are limited by flexibility, biosafety, and manufacturing costs, which create large barriers for wider applications. Here, we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface, robustness of microneedles to penetrate the skin without fracture, and a simplified process to allow mass production. The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording. The normalized electrode–skin contact impedance reaches 0.98 kΩ cm(2) at 1 kHz and 1.50 kΩ cm(2) at 10 Hz, a record low value compared to previous reports and approximately 1/250 of the standard electrodes. The morphology, biosafety, and electrical/mechanical properties are fully characterized, and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized. The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording (over 8 h per night), providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00870-0. Springer Nature Singapore 2022-06-14 /pmc/articles/PMC9198145/ /pubmed/35699782 http://dx.doi.org/10.1007/s40820-022-00870-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Junshi Ma, Yundong Huang, Dong Wang, Zhongyan Zhang, Zhitong Ren, Yingjie Hong, Mengyue Chen, Yufeng Li, Tingyu Shi, Xiaoyi Cao, Lu Zhang, Jiayan Jiao, Bingli Liu, Junhua Sun, Hongqiang Li, Zhihong High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title | High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title_full | High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title_fullStr | High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title_full_unstemmed | High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title_short | High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography |
title_sort | high-performance flexible microneedle array as a low-impedance surface biopotential dry electrode for wearable electrophysiological recording and polysomnography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198145/ https://www.ncbi.nlm.nih.gov/pubmed/35699782 http://dx.doi.org/10.1007/s40820-022-00870-0 |
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