Chemistry and bioactivities of natural steroidal alkaloids

Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone ac...

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Autores principales: Xiang, Mei-Ling, Hu, Bin-Yuan, Qi, Zi-Heng, Wang, Xiao-Na, Xie, Tian-Zhen, Wang, Zhao-Jie, Ma, Dan-Yu, Zeng, Qi, Luo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198197/
https://www.ncbi.nlm.nih.gov/pubmed/35701630
http://dx.doi.org/10.1007/s13659-022-00345-0
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author Xiang, Mei-Ling
Hu, Bin-Yuan
Qi, Zi-Heng
Wang, Xiao-Na
Xie, Tian-Zhen
Wang, Zhao-Jie
Ma, Dan-Yu
Zeng, Qi
Luo, Xiao-Dong
author_facet Xiang, Mei-Ling
Hu, Bin-Yuan
Qi, Zi-Heng
Wang, Xiao-Na
Xie, Tian-Zhen
Wang, Zhao-Jie
Ma, Dan-Yu
Zeng, Qi
Luo, Xiao-Dong
author_sort Xiang, Mei-Ling
collection PubMed
description Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga(®)), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.
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spelling pubmed-91981972022-06-16 Chemistry and bioactivities of natural steroidal alkaloids Xiang, Mei-Ling Hu, Bin-Yuan Qi, Zi-Heng Wang, Xiao-Na Xie, Tian-Zhen Wang, Zhao-Jie Ma, Dan-Yu Zeng, Qi Luo, Xiao-Dong Nat Prod Bioprospect Review Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga(®)), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited. Springer Nature Singapore 2022-06-15 /pmc/articles/PMC9198197/ /pubmed/35701630 http://dx.doi.org/10.1007/s13659-022-00345-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Xiang, Mei-Ling
Hu, Bin-Yuan
Qi, Zi-Heng
Wang, Xiao-Na
Xie, Tian-Zhen
Wang, Zhao-Jie
Ma, Dan-Yu
Zeng, Qi
Luo, Xiao-Dong
Chemistry and bioactivities of natural steroidal alkaloids
title Chemistry and bioactivities of natural steroidal alkaloids
title_full Chemistry and bioactivities of natural steroidal alkaloids
title_fullStr Chemistry and bioactivities of natural steroidal alkaloids
title_full_unstemmed Chemistry and bioactivities of natural steroidal alkaloids
title_short Chemistry and bioactivities of natural steroidal alkaloids
title_sort chemistry and bioactivities of natural steroidal alkaloids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198197/
https://www.ncbi.nlm.nih.gov/pubmed/35701630
http://dx.doi.org/10.1007/s13659-022-00345-0
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