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Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation

BACKGROUND: The DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly low and cell-specific flux through these pathways, and similar activities of OADH and ubiquitously expressed 2-oxoglutarate dehydrogenase (...

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Detalles Bibliográficos
Autores principales:	Boyko, Alexandra I., Karlina, Irina S., Zavileyskiy, Lev G., Aleshin, Vasily A., Artiukhov, Artem V., Kaehne, Thilo, Ksenofontov, Alexander L., Ryabov, Sergey I., Graf, Anastasia V., Tramonti, Angela, Bunik, Victoria I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198357/ https://www.ncbi.nlm.nih.gov/pubmed/35721081 http://dx.doi.org/10.3389/fmed.2022.896263

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