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Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application

In order to expand the promise of regenerative medicine using allogeneic induced pluripotent stem cells (iPSCs), precise and efficient genome editing of human leukocyte antigen (HLA) genes would be advantageous to minimize the immune rejection caused by mismatches of HLA type. However, clinical-grad...

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Detalles Bibliográficos
Autores principales:	Kitano, Yuko, Nishimura, Sayaka, Kato, Tomoaki M., Ueda, Anna, Takigawa, Kaho, Umekage, Masafumi, Nomura, Masaki, Kawakami, Ayane, Ogawa, Haruna, Xu, Huaigeng, Hotta, Akitsu, Takasu, Naoko, Tsukahara, Masayoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198376/ https://www.ncbi.nlm.nih.gov/pubmed/35755947 http://dx.doi.org/10.1016/j.omtm.2022.05.010

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