Cargando…

Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus

OBJECTIVE: To investigate the relationship between plasma vitamin D2(VD2) and type 2 diabetes(T2DM). METHOD: Data from electronic medical records of 797 inpatients treated at Sun Yat Sen Memorial Hospital, Sun Yat-sen University between June 24, 2019 and December 24, 2020 were collected, and a total...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Jing-Wan, Huang, Bing, Wang, Shuang, Song, Dan, Xu, Jing, Cui, Ying, Guo, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198404/
https://www.ncbi.nlm.nih.gov/pubmed/35721707
http://dx.doi.org/10.3389/fendo.2022.897316
_version_ 1784727607885955072
author Qi, Jing-Wan
Huang, Bing
Wang, Shuang
Song, Dan
Xu, Jing
Cui, Ying
Guo, Bin
author_facet Qi, Jing-Wan
Huang, Bing
Wang, Shuang
Song, Dan
Xu, Jing
Cui, Ying
Guo, Bin
author_sort Qi, Jing-Wan
collection PubMed
description OBJECTIVE: To investigate the relationship between plasma vitamin D2(VD2) and type 2 diabetes(T2DM). METHOD: Data from electronic medical records of 797 inpatients treated at Sun Yat Sen Memorial Hospital, Sun Yat-sen University between June 24, 2019 and December 24, 2020 were collected, and a total of 596 patients were enrolled after screening based on inclusion and exclusion criteria. Patients were divided into diabetic and non-diabetic groups according to whether they had T2DM. The Wilcoxon rank sum test was finally selected for the analysis of differences between groups according to the distribution of patients’ plasma VD2, and logistic regression models were used to find the corresponding influencing factors. RESULT: Of the 596 hospitalized patients, 138 (23.15%) were diagnosed with T2DM. The Wilcoxon test showed no statistically significant difference in plasma VD2 concentrations between the T2DM and non-T2DM groups (p=0.833). After adjustment for confounders by multivariate logistic regression, there was still no significant difference in plasma VD2 concentrations between the two groups (P=0.316, OR: 1.15 (0.88,1.49)). The uncorrelated relationship between VD2 and T2DM was not found to change after incorporating 12 indicators, including demographic characteristics, laboratory indicators and complications, into the logistic regression model by 3 steps, even the OR (1.08 (0.92,1.26)) did not change in the 3 models. Similarly, the adjusted ORs agreed that there was no statistical association between VD2 and T2DM. CONCLUSION: VD2 levels are similar in patients with T2DM compared to those without T2DM. Clinical caution should be exercised in giving VD2 supplementation to patients with T2DM unless other diseases requiring VD2 supplementation (e.g., rickets, osteoporosis) are present.
format Online
Article
Text
id pubmed-9198404
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91984042022-06-16 Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus Qi, Jing-Wan Huang, Bing Wang, Shuang Song, Dan Xu, Jing Cui, Ying Guo, Bin Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: To investigate the relationship between plasma vitamin D2(VD2) and type 2 diabetes(T2DM). METHOD: Data from electronic medical records of 797 inpatients treated at Sun Yat Sen Memorial Hospital, Sun Yat-sen University between June 24, 2019 and December 24, 2020 were collected, and a total of 596 patients were enrolled after screening based on inclusion and exclusion criteria. Patients were divided into diabetic and non-diabetic groups according to whether they had T2DM. The Wilcoxon rank sum test was finally selected for the analysis of differences between groups according to the distribution of patients’ plasma VD2, and logistic regression models were used to find the corresponding influencing factors. RESULT: Of the 596 hospitalized patients, 138 (23.15%) were diagnosed with T2DM. The Wilcoxon test showed no statistically significant difference in plasma VD2 concentrations between the T2DM and non-T2DM groups (p=0.833). After adjustment for confounders by multivariate logistic regression, there was still no significant difference in plasma VD2 concentrations between the two groups (P=0.316, OR: 1.15 (0.88,1.49)). The uncorrelated relationship between VD2 and T2DM was not found to change after incorporating 12 indicators, including demographic characteristics, laboratory indicators and complications, into the logistic regression model by 3 steps, even the OR (1.08 (0.92,1.26)) did not change in the 3 models. Similarly, the adjusted ORs agreed that there was no statistical association between VD2 and T2DM. CONCLUSION: VD2 levels are similar in patients with T2DM compared to those without T2DM. Clinical caution should be exercised in giving VD2 supplementation to patients with T2DM unless other diseases requiring VD2 supplementation (e.g., rickets, osteoporosis) are present. Frontiers Media S.A. 2022-06-01 /pmc/articles/PMC9198404/ /pubmed/35721707 http://dx.doi.org/10.3389/fendo.2022.897316 Text en Copyright © 2022 Qi, Huang, Wang, Song, Xu, Cui and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Qi, Jing-Wan
Huang, Bing
Wang, Shuang
Song, Dan
Xu, Jing
Cui, Ying
Guo, Bin
Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title_full Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title_fullStr Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title_full_unstemmed Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title_short Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus
title_sort association between plasma vitamin d2 and type 2 diabetes mellitus
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198404/
https://www.ncbi.nlm.nih.gov/pubmed/35721707
http://dx.doi.org/10.3389/fendo.2022.897316
work_keys_str_mv AT qijingwan associationbetweenplasmavitamind2andtype2diabetesmellitus
AT huangbing associationbetweenplasmavitamind2andtype2diabetesmellitus
AT wangshuang associationbetweenplasmavitamind2andtype2diabetesmellitus
AT songdan associationbetweenplasmavitamind2andtype2diabetesmellitus
AT xujing associationbetweenplasmavitamind2andtype2diabetesmellitus
AT cuiying associationbetweenplasmavitamind2andtype2diabetesmellitus
AT guobin associationbetweenplasmavitamind2andtype2diabetesmellitus