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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and interferes with the cohesion of duplicated centrosomes. W...

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Detalles Bibliográficos
Autores principales:	Fdez, Elena, Madero-Pérez, Jesús, Lara Ordóñez, Antonio J., Naaldijk, Yahaira, Fasiczka, Rachel, Aiastui, Ana, Ruiz-Martínez, Javier, López de Munain, Adolfo, Cowley, Sally A., Wade-Martins, Richard, Hilfiker, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198432/ https://www.ncbi.nlm.nih.gov/pubmed/35721463 http://dx.doi.org/10.1016/j.isci.2022.104476

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