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Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis
BACKGROUND: Hypoxemia and fluctuations in respiratory mechanics parameters are common during one-lung ventilation (OLV) in thoracic surgery. Additionally, the incidence of postoperative pulmonary complications (PPC(S)) in thoracic surgery is higher than that in other surgeries. Previous studies have...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198650/ https://www.ncbi.nlm.nih.gov/pubmed/35722525 http://dx.doi.org/10.3389/fsurg.2022.914984 |
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author | Li, Xuan Xue, Wenqiang Zhang, Qinyu Zhu, Yuyang Fang, Yu Huang, Jie |
author_facet | Li, Xuan Xue, Wenqiang Zhang, Qinyu Zhu, Yuyang Fang, Yu Huang, Jie |
author_sort | Li, Xuan |
collection | PubMed |
description | BACKGROUND: Hypoxemia and fluctuations in respiratory mechanics parameters are common during one-lung ventilation (OLV) in thoracic surgery. Additionally, the incidence of postoperative pulmonary complications (PPC(S)) in thoracic surgery is higher than that in other surgeries. Previous studies have demonstrated that driving pressure-oriented ventilation can reduce both mortality in patients with acute respiratory distress syndrome (ARDS) and the incidence of PPC(S) in patients undergoing general anesthesia. Our aim was to determine whether driving pressure-oriented ventilation improves intraoperative physiology and outcomes in patients undergoing thoracic surgery. METHODS: We searched MEDLINE via PubMed, Embase, Cochrane, Web of Science, and ClinicalTrials.gov and performed a meta-analysis to compare the effects of driving pressure-oriented ventilation with other ventilation strategies on patients undergoing OLV. The primary outcome was the PaO(2)/FiO(2) ratio (P/F ratio) during OLV. The secondary outcomes were the incidence of PPC(S) during follow-up, compliance of the respiratory system during OLV, and mean arterial pressure during OLV. RESULTS: This review included seven studies, with a total of 640 patients. The PaO(2)/FiO(2) ratio was higher during OLV in the driving pressure-oriented ventilation group (mean difference [MD]: 44.96; 95% confidence interval [CI], 24.22–65.70.32; I(2): 58%; P < 0.0001). The incidence of PPC(S) was lower (OR: 0.58; 95% CI, 0.34–0.99; I(2): 0%; P = 0.04) and the compliance of the respiratory system was higher (MD: 6.15; 95% CI, 3.97–8.32; I(2): 57%; P < 0.00001) in the driving pressure-oriented group during OLV. We did not find a significant difference in the mean arterial pressure between the two groups. CONCLUSION: Driving pressure-oriented ventilation during OLV in patients undergoing thoracic surgery was associated with better perioperative oxygenation, fewer PPC(S), and improved compliance of the respiratory system. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier: CRD42021297063. |
format | Online Article Text |
id | pubmed-9198650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91986502022-06-16 Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis Li, Xuan Xue, Wenqiang Zhang, Qinyu Zhu, Yuyang Fang, Yu Huang, Jie Front Surg Surgery BACKGROUND: Hypoxemia and fluctuations in respiratory mechanics parameters are common during one-lung ventilation (OLV) in thoracic surgery. Additionally, the incidence of postoperative pulmonary complications (PPC(S)) in thoracic surgery is higher than that in other surgeries. Previous studies have demonstrated that driving pressure-oriented ventilation can reduce both mortality in patients with acute respiratory distress syndrome (ARDS) and the incidence of PPC(S) in patients undergoing general anesthesia. Our aim was to determine whether driving pressure-oriented ventilation improves intraoperative physiology and outcomes in patients undergoing thoracic surgery. METHODS: We searched MEDLINE via PubMed, Embase, Cochrane, Web of Science, and ClinicalTrials.gov and performed a meta-analysis to compare the effects of driving pressure-oriented ventilation with other ventilation strategies on patients undergoing OLV. The primary outcome was the PaO(2)/FiO(2) ratio (P/F ratio) during OLV. The secondary outcomes were the incidence of PPC(S) during follow-up, compliance of the respiratory system during OLV, and mean arterial pressure during OLV. RESULTS: This review included seven studies, with a total of 640 patients. The PaO(2)/FiO(2) ratio was higher during OLV in the driving pressure-oriented ventilation group (mean difference [MD]: 44.96; 95% confidence interval [CI], 24.22–65.70.32; I(2): 58%; P < 0.0001). The incidence of PPC(S) was lower (OR: 0.58; 95% CI, 0.34–0.99; I(2): 0%; P = 0.04) and the compliance of the respiratory system was higher (MD: 6.15; 95% CI, 3.97–8.32; I(2): 57%; P < 0.00001) in the driving pressure-oriented group during OLV. We did not find a significant difference in the mean arterial pressure between the two groups. CONCLUSION: Driving pressure-oriented ventilation during OLV in patients undergoing thoracic surgery was associated with better perioperative oxygenation, fewer PPC(S), and improved compliance of the respiratory system. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier: CRD42021297063. Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9198650/ /pubmed/35722525 http://dx.doi.org/10.3389/fsurg.2022.914984 Text en Copyright © 2022 Li, Xue, Zhang, Zhu, Fang and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Li, Xuan Xue, Wenqiang Zhang, Qinyu Zhu, Yuyang Fang, Yu Huang, Jie Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title | Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title_full | Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title_fullStr | Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title_short | Effect of Driving Pressure-Oriented Ventilation on Patients Undergoing One-Lung Ventilation During Thoracic Surgery: A Systematic Review and Meta-Analysis |
title_sort | effect of driving pressure-oriented ventilation on patients undergoing one-lung ventilation during thoracic surgery: a systematic review and meta-analysis |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198650/ https://www.ncbi.nlm.nih.gov/pubmed/35722525 http://dx.doi.org/10.3389/fsurg.2022.914984 |
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