A close shave: How SARS-CoV-2 induces the loss of cilia

Wang et al. report in this issue (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2(ZYG11B), leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-...

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Detalles Bibliográficos
Autores principales: Fonseca, Barbara F., Chakrabarti, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198720/
https://www.ncbi.nlm.nih.gov/pubmed/35695891
http://dx.doi.org/10.1083/jcb.202206023
Descripción
Sumario:Wang et al. report in this issue (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2(ZYG11B), leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

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