A close shave: How SARS-CoV-2 induces the loss of cilia

Wang et al. report in this issue (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2(ZYG11B), leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-...

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Detalles Bibliográficos
Autores principales: Fonseca, Barbara F., Chakrabarti, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198720/
https://www.ncbi.nlm.nih.gov/pubmed/35695891
http://dx.doi.org/10.1083/jcb.202206023
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author Fonseca, Barbara F.
Chakrabarti, Lisa A.
author_facet Fonseca, Barbara F.
Chakrabarti, Lisa A.
author_sort Fonseca, Barbara F.
collection PubMed
description Wang et al. report in this issue (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2(ZYG11B), leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.
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spelling pubmed-91987202022-06-17 A close shave: How SARS-CoV-2 induces the loss of cilia Fonseca, Barbara F. Chakrabarti, Lisa A. J Cell Biol Spotlight Wang et al. report in this issue (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2(ZYG11B), leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree. Rockefeller University Press 2022-06-13 /pmc/articles/PMC9198720/ /pubmed/35695891 http://dx.doi.org/10.1083/jcb.202206023 Text en © 2022 Fonseca and Chakrabarti https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Fonseca, Barbara F.
Chakrabarti, Lisa A.
A close shave: How SARS-CoV-2 induces the loss of cilia
title A close shave: How SARS-CoV-2 induces the loss of cilia
title_full A close shave: How SARS-CoV-2 induces the loss of cilia
title_fullStr A close shave: How SARS-CoV-2 induces the loss of cilia
title_full_unstemmed A close shave: How SARS-CoV-2 induces the loss of cilia
title_short A close shave: How SARS-CoV-2 induces the loss of cilia
title_sort close shave: how sars-cov-2 induces the loss of cilia
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198720/
https://www.ncbi.nlm.nih.gov/pubmed/35695891
http://dx.doi.org/10.1083/jcb.202206023
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