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Increased Serum Beta-Secretase 1 Activity is an Early Marker of Alzheimer’s Disease

BACKGROUND: Beta-site APP cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid-β (Aβ) plaques formation. BACE1 activity is increased in brains of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and plasma levels of BACE1 appears to reflect those in the brains....

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Detalles Bibliográficos
Autores principales:	Nicsanu, Roland, Cervellati, Carlo, Benussi, Luisa, Squitti, Rosanna, Zanardini, Roberta, Rosta, Valentina, Trentini, Alessandro, Ferrari, Clarissa, Saraceno, Claudia, Longobardi, Antonio, Bellini, Sonia, Binetti, Giuliano, Zanetti, Orazio, Zuliani, Giovanni, Ghidoni, Roberta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198762/ https://www.ncbi.nlm.nih.gov/pubmed/35275540 http://dx.doi.org/10.3233/JAD-215542

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