Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits

BACKGROUND: Preclinical rodent models for Parkinson’s disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structure...

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Detalles Bibliográficos
Autores principales: Negrini, Matilde, Tomasello, Giuseppe, Davidsson, Marcus, Fenyi, Alexis, Adant, Cécile, Hauser, Swantje, Espa, Elena, Gubinelli, Francesco, Manfredsson, Fredric P., Melki, Ronald, Heuer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198765/
https://www.ncbi.nlm.nih.gov/pubmed/35213388
http://dx.doi.org/10.3233/JPD-212555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198765/
https://www.ncbi.nlm.nih.gov/pubmed/35213388
http://dx.doi.org/10.3233/JPD-212555

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