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EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report

BACKGROUND: A 79-year-old woman was admitted to the Neurology Clinic of the University of Chieti-Pescara for a syncope. At admission, the occurrence of an acute stroke was ruled out. Her cognitive status was unimpaired. After three days from the hospitalization, the patient experienced an episode of...

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Autores principales: Carrarini, Claudia, De Rosa, Matteo Alessandro, Calisi, Dario, Digiovanni, Anna, Salute, Pierpaolo, Dono, Fedele, Evangelista, Giacomo, Consoli, Stefano, Russo, Mirella, Ferri, Laura, D’Ardes, Damiano, Mattoli, Maria Vittoria, Cipollone, Francesco, Onofrj, Marco, Bonanni, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198785/
https://www.ncbi.nlm.nih.gov/pubmed/35719713
http://dx.doi.org/10.3233/ADR-220017
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author Carrarini, Claudia
De Rosa, Matteo Alessandro
Calisi, Dario
Digiovanni, Anna
Salute, Pierpaolo
Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Russo, Mirella
Ferri, Laura
D’Ardes, Damiano
Mattoli, Maria Vittoria
Cipollone, Francesco
Onofrj, Marco
Bonanni, Laura
author_facet Carrarini, Claudia
De Rosa, Matteo Alessandro
Calisi, Dario
Digiovanni, Anna
Salute, Pierpaolo
Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Russo, Mirella
Ferri, Laura
D’Ardes, Damiano
Mattoli, Maria Vittoria
Cipollone, Francesco
Onofrj, Marco
Bonanni, Laura
author_sort Carrarini, Claudia
collection PubMed
description BACKGROUND: A 79-year-old woman was admitted to the Neurology Clinic of the University of Chieti-Pescara for a syncope. At admission, the occurrence of an acute stroke was ruled out. Her cognitive status was unimpaired. After three days from the hospitalization, the patient experienced an episode of mixed delirium. OBJECTIVE: The present case report shows a case of delirium-onset dementia with Lewy bodies (DLB) with a specific electroencephalographic (EEG) pattern from its prodromal stage. METHODS: Delirium was assessed by 4AT test. During the hospitalization, the patient underwent a quantitative EEG (QEEG) with spectral analysis. At six months from the episode of delirium, she was tested by neuropsychological evaluation, QEEG, and (18)F-fluorodeoxyglucose PET/CT to assess the onset of a possible cognitive decline. RESULTS: At baseline, the QEEG exam showed a dominant frequency (DF) in the pre-alpha band (7.5 Hz) with a dominant frequency variability (DFV) of 2 Hz. This pattern is typical of DLB at early stage. After six months, she reported attention deficits in association with cognitive fluctuation and REM sleep behavior disorder. The neurological examination revealed signs of parkinsonism. Cognitive status resulted to be impaired (MoCA = 15/30). QEEG recording confirmed the presence of a DLB-typical pattern (DF = 7.5 Hz, DFV = 2.5 Hz). The (18)F-FDG-PET/CT showed a moderate bilateral posterior hypometabolism (occipital and temporal cortex), with relative sparing of the posterior cingulate cortex compared to cuneus/precuneus (Cingulate Island sign), and mild bilateral hypometabolism in frontal regions (suggestive of a DLB diagnosis). CONCLUSION: EEGs may represent supportive and validated biomarkers for delirium-onset prodromal DLB.
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spelling pubmed-91987852022-06-16 EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report Carrarini, Claudia De Rosa, Matteo Alessandro Calisi, Dario Digiovanni, Anna Salute, Pierpaolo Dono, Fedele Evangelista, Giacomo Consoli, Stefano Russo, Mirella Ferri, Laura D’Ardes, Damiano Mattoli, Maria Vittoria Cipollone, Francesco Onofrj, Marco Bonanni, Laura J Alzheimers Dis Rep Research Report BACKGROUND: A 79-year-old woman was admitted to the Neurology Clinic of the University of Chieti-Pescara for a syncope. At admission, the occurrence of an acute stroke was ruled out. Her cognitive status was unimpaired. After three days from the hospitalization, the patient experienced an episode of mixed delirium. OBJECTIVE: The present case report shows a case of delirium-onset dementia with Lewy bodies (DLB) with a specific electroencephalographic (EEG) pattern from its prodromal stage. METHODS: Delirium was assessed by 4AT test. During the hospitalization, the patient underwent a quantitative EEG (QEEG) with spectral analysis. At six months from the episode of delirium, she was tested by neuropsychological evaluation, QEEG, and (18)F-fluorodeoxyglucose PET/CT to assess the onset of a possible cognitive decline. RESULTS: At baseline, the QEEG exam showed a dominant frequency (DF) in the pre-alpha band (7.5 Hz) with a dominant frequency variability (DFV) of 2 Hz. This pattern is typical of DLB at early stage. After six months, she reported attention deficits in association with cognitive fluctuation and REM sleep behavior disorder. The neurological examination revealed signs of parkinsonism. Cognitive status resulted to be impaired (MoCA = 15/30). QEEG recording confirmed the presence of a DLB-typical pattern (DF = 7.5 Hz, DFV = 2.5 Hz). The (18)F-FDG-PET/CT showed a moderate bilateral posterior hypometabolism (occipital and temporal cortex), with relative sparing of the posterior cingulate cortex compared to cuneus/precuneus (Cingulate Island sign), and mild bilateral hypometabolism in frontal regions (suggestive of a DLB diagnosis). CONCLUSION: EEGs may represent supportive and validated biomarkers for delirium-onset prodromal DLB. IOS Press 2022-05-10 /pmc/articles/PMC9198785/ /pubmed/35719713 http://dx.doi.org/10.3233/ADR-220017 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Report
Carrarini, Claudia
De Rosa, Matteo Alessandro
Calisi, Dario
Digiovanni, Anna
Salute, Pierpaolo
Dono, Fedele
Evangelista, Giacomo
Consoli, Stefano
Russo, Mirella
Ferri, Laura
D’Ardes, Damiano
Mattoli, Maria Vittoria
Cipollone, Francesco
Onofrj, Marco
Bonanni, Laura
EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title_full EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title_fullStr EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title_full_unstemmed EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title_short EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
title_sort eeg abnormalities during delirium as a prodromal feature of dementia with lewy bodies: a case report
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198785/
https://www.ncbi.nlm.nih.gov/pubmed/35719713
http://dx.doi.org/10.3233/ADR-220017
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