Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions

INTRODUCTION: Previously, we performed gene knockout (KO) of interleukin-2 receptor gamma (IL2RG) in porcine fetal fibroblasts using zinc finger nuclease-encoding mRNAs, subsequently generating IL2RG KO pigs using these cells through somatic cell nuclear transfer. The IL2RG KO pigs lacked a thymus a...

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Detalles Bibliográficos
Autores principales: Hasegawa, Koki, Nakano, Kazuaki, Nagaya, Masaki, Watanabe, Masahito, Uchikura, Ayuko, Matsunari, Hitomi, Umeyama, Kazuhiro, Kobayashi, Eiji, Nagashima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198816/
https://www.ncbi.nlm.nih.gov/pubmed/35765545
http://dx.doi.org/10.1016/j.reth.2022.05.010

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