Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update

The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling errors. Donor derived cell free DNA (dd-cfDNA) is b...

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Autores principales: Kant, Sam, Brennan, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Health Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198901/
https://www.ncbi.nlm.nih.gov/pubmed/35721467
http://dx.doi.org/10.3389/ti.2022.10448
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author Kant, Sam
Brennan, Daniel C.
author_facet Kant, Sam
Brennan, Daniel C.
author_sort Kant, Sam
collection PubMed
description The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling errors. Donor derived cell free DNA (dd-cfDNA) is being employed as a biomarker that addresses limitations of these surveillance methods, albeit has inherent drawbacks. This review provides an update on the enhanced understanding of dd-cfDNA and its expanded use beyond the conventional indication of detecting allograft rejection.
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spelling pubmed-91989012022-06-16 Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update Kant, Sam Brennan, Daniel C. Transpl Int Health Archive The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling errors. Donor derived cell free DNA (dd-cfDNA) is being employed as a biomarker that addresses limitations of these surveillance methods, albeit has inherent drawbacks. This review provides an update on the enhanced understanding of dd-cfDNA and its expanded use beyond the conventional indication of detecting allograft rejection. Frontiers Media S.A. 2022-06-01 /pmc/articles/PMC9198901/ /pubmed/35721467 http://dx.doi.org/10.3389/ti.2022.10448 Text en Copyright © 2022 Kant and Brennan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Kant, Sam
Brennan, Daniel C.
Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title_full Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title_fullStr Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title_full_unstemmed Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title_short Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update
title_sort donor derived cell free dna in kidney transplantation: the circa 2020–2021 update
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198901/
https://www.ncbi.nlm.nih.gov/pubmed/35721467
http://dx.doi.org/10.3389/ti.2022.10448
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