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SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa

The intrinsic tenase (Xase) complex, formed by factors (f) VIIIa and fIXa, forms on activated platelet surfaces and catalyzes the activation of factor X to Xa, stimulating thrombin production in the blood coagulation cascade. The structural organization of the membrane-bound Xase complex remains lar...

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Detalles Bibliográficos
Autores principales:	Childers, Kenneth C., Peters, Shaun C., Lollar, Pete, Spencer, Harold Trent, Doering, Christopher B., Spiegel, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198903/ https://www.ncbi.nlm.nih.gov/pubmed/35255502 http://dx.doi.org/10.1182/bloodadvances.2021005874

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