Genetic variants of PKLR are associated with acute pain in sickle cell disease

Acute pain, the most prominent complication of sickle cell disease (SCD), results from vaso-occlusion triggered by sickling of deoxygenated red blood cells (RBCs). Concentration of 2,3-diphosphoglycerate (2,3-DPG) in RBCs promotes deoxygenation by preferentially binding to the low-affinity T conform...

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Detalles Bibliográficos
Autores principales: Wang, Xunde, Gardner, Kate, Tegegn, Mickias B., Dalgard, Clifton L., Alba, Camille, Menzel, Stephan, Patel, Hamel, Pirooznia, Mehdi, Fu, Yi-Ping, Seifuddin, Fayaz T., Thein, Swee Lay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198922/
https://www.ncbi.nlm.nih.gov/pubmed/35271708
http://dx.doi.org/10.1182/bloodadvances.2021006668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198922/
https://www.ncbi.nlm.nih.gov/pubmed/35271708
http://dx.doi.org/10.1182/bloodadvances.2021006668

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