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Genetic variants of PKLR are associated with acute pain in sickle cell disease

Acute pain, the most prominent complication of sickle cell disease (SCD), results from vaso-occlusion triggered by sickling of deoxygenated red blood cells (RBCs). Concentration of 2,3-diphosphoglycerate (2,3-DPG) in RBCs promotes deoxygenation by preferentially binding to the low-affinity T conform...

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Detalles Bibliográficos
Autores principales:	Wang, Xunde, Gardner, Kate, Tegegn, Mickias B., Dalgard, Clifton L., Alba, Camille, Menzel, Stephan, Patel, Hamel, Pirooznia, Mehdi, Fu, Yi-Ping, Seifuddin, Fayaz T., Thein, Swee Lay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Stimulus Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198922/ https://www.ncbi.nlm.nih.gov/pubmed/35271708 http://dx.doi.org/10.1182/bloodadvances.2021006668

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