Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C

Hemophilia A and B are hereditary coagulation defects resulting in unstable blood clotting and recurrent bleeding. Current factor replacement therapies have major limitations such as the short half-life of the factors and development of inhibitors. Alternative approaches to rebalance the hemostasis...

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Detalles Bibliográficos
Autores principales: Jiang, Miao, Yang, Fei, Jiang, Yizhi, Cheng, Lu, Han, Jingjing, Yi, Jiawei, Zhang, Guige, Ma, Zhenni, Cao, Lijuan, Zuo, Bin, Zhou, Lixia, Huang, Lulu, Niu, Siying, Xia, Zhisong, Zhou, Xuefeng, Bai, Xia, Esmon, Naomi L., Ruan, Changgeng, Xia, Lijun, Han, Yue, Esmon, Charles T., Wu, Depei, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198932/
https://www.ncbi.nlm.nih.gov/pubmed/35390147
http://dx.doi.org/10.1182/bloodadvances.2021006214

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