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A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways

Zika virus (ZIKV) is an arbovirus mainly transmitted by mosquitos of the genus Aedes. The first cases of ZIKV infection in South America occurred in Brazil in 2015. The infection in humans causes diverse symptoms from asymptomatic to a syndrome-like dengue infection with fever, arthralgia, and myalg...

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Autores principales: Carvalho-Silva, Ana Carolina, Da Silva Junior, Almir Ribeiro, Rigaud, Vagner Oliveira-Carvalho, Martins, Waleska Kerllen, Coelho, Verônica, Pfrimer, Irmtraut Araci Hoffmann, Kalil, Jorge, Fonseca, Simone Gonçalves, Cunha-Neto, Edecio, Ferreira, Ludmila Rodrigues Pinto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199004/
https://www.ncbi.nlm.nih.gov/pubmed/35719399
http://dx.doi.org/10.3389/fgene.2022.857728
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author Carvalho-Silva, Ana Carolina
Da Silva Junior, Almir Ribeiro
Rigaud, Vagner Oliveira-Carvalho
Martins, Waleska Kerllen
Coelho, Verônica
Pfrimer, Irmtraut Araci Hoffmann
Kalil, Jorge
Fonseca, Simone Gonçalves
Cunha-Neto, Edecio
Ferreira, Ludmila Rodrigues Pinto
author_facet Carvalho-Silva, Ana Carolina
Da Silva Junior, Almir Ribeiro
Rigaud, Vagner Oliveira-Carvalho
Martins, Waleska Kerllen
Coelho, Verônica
Pfrimer, Irmtraut Araci Hoffmann
Kalil, Jorge
Fonseca, Simone Gonçalves
Cunha-Neto, Edecio
Ferreira, Ludmila Rodrigues Pinto
author_sort Carvalho-Silva, Ana Carolina
collection PubMed
description Zika virus (ZIKV) is an arbovirus mainly transmitted by mosquitos of the genus Aedes. The first cases of ZIKV infection in South America occurred in Brazil in 2015. The infection in humans causes diverse symptoms from asymptomatic to a syndrome-like dengue infection with fever, arthralgia, and myalgia. Furthermore, ZIKV infection during pregnancy is associated with fetal microcephaly and neurological disorders. The identification of host molecular mechanisms responsible for the modulation of different signaling pathways in response to ZIKV is the first step to finding potential biomarkers and therapeutic targets and understanding disease outcomes. In the last decade, it has been shown that microRNAs (miRNAs) are important post-transcriptional regulators involved in virtually all cellular processes. miRNAs present in body fluids can not only serve as key biomarkers for diagnostics and prognosis of human disorders but also contribute to cellular signaling offering new insights into pathological mechanisms. Here, we describe for the first time ZIKV-induced changes in miRNA plasma levels in patients during the acute and recovery phases of infection. We observed that during ZIKV acute infection, among the dysregulated miRNAs (DMs), the majority is with decreased levels when compared to convalescent and control patients. We used systems biology tools to build and highlight biological interactions between miRNAs and their multiple direct and indirect target molecules. Among the 24 DMs identified in ZIKV + patients, miR-146, miR-125a-5p, miR-30-5p, and miR-142-3p were related to signaling pathways modulated during infection and immune response. The results presented here are an effort to open new vistas for the key roles of miRNAs during ZIKV infection.
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spelling pubmed-91990042022-06-16 A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways Carvalho-Silva, Ana Carolina Da Silva Junior, Almir Ribeiro Rigaud, Vagner Oliveira-Carvalho Martins, Waleska Kerllen Coelho, Verônica Pfrimer, Irmtraut Araci Hoffmann Kalil, Jorge Fonseca, Simone Gonçalves Cunha-Neto, Edecio Ferreira, Ludmila Rodrigues Pinto Front Genet Genetics Zika virus (ZIKV) is an arbovirus mainly transmitted by mosquitos of the genus Aedes. The first cases of ZIKV infection in South America occurred in Brazil in 2015. The infection in humans causes diverse symptoms from asymptomatic to a syndrome-like dengue infection with fever, arthralgia, and myalgia. Furthermore, ZIKV infection during pregnancy is associated with fetal microcephaly and neurological disorders. The identification of host molecular mechanisms responsible for the modulation of different signaling pathways in response to ZIKV is the first step to finding potential biomarkers and therapeutic targets and understanding disease outcomes. In the last decade, it has been shown that microRNAs (miRNAs) are important post-transcriptional regulators involved in virtually all cellular processes. miRNAs present in body fluids can not only serve as key biomarkers for diagnostics and prognosis of human disorders but also contribute to cellular signaling offering new insights into pathological mechanisms. Here, we describe for the first time ZIKV-induced changes in miRNA plasma levels in patients during the acute and recovery phases of infection. We observed that during ZIKV acute infection, among the dysregulated miRNAs (DMs), the majority is with decreased levels when compared to convalescent and control patients. We used systems biology tools to build and highlight biological interactions between miRNAs and their multiple direct and indirect target molecules. Among the 24 DMs identified in ZIKV + patients, miR-146, miR-125a-5p, miR-30-5p, and miR-142-3p were related to signaling pathways modulated during infection and immune response. The results presented here are an effort to open new vistas for the key roles of miRNAs during ZIKV infection. Frontiers Media S.A. 2022-06-01 /pmc/articles/PMC9199004/ /pubmed/35719399 http://dx.doi.org/10.3389/fgene.2022.857728 Text en Copyright © 2022 Carvalho-Silva, Da Silva Junior, Rigaud, Martins, Coelho, Pfrimer, Kalil, Fonseca, Cunha-Neto and Ferreira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Carvalho-Silva, Ana Carolina
Da Silva Junior, Almir Ribeiro
Rigaud, Vagner Oliveira-Carvalho
Martins, Waleska Kerllen
Coelho, Verônica
Pfrimer, Irmtraut Araci Hoffmann
Kalil, Jorge
Fonseca, Simone Gonçalves
Cunha-Neto, Edecio
Ferreira, Ludmila Rodrigues Pinto
A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title_full A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title_fullStr A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title_full_unstemmed A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title_short A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways
title_sort major downregulation of circulating micrornas in zika acutely infected patients: potential implications in innate and adaptive immune response signaling pathways
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199004/
https://www.ncbi.nlm.nih.gov/pubmed/35719399
http://dx.doi.org/10.3389/fgene.2022.857728
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