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Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms

In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural...

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Autores principales: Jahn, Kelly N., Hancock, Kenneth E., Maison, Stéphane F., Polley, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Acoustical Society of America 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199082/
https://www.ncbi.nlm.nih.gov/pubmed/35719240
http://dx.doi.org/10.1121/10.0011694
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author Jahn, Kelly N.
Hancock, Kenneth E.
Maison, Stéphane F.
Polley, Daniel B.
author_facet Jahn, Kelly N.
Hancock, Kenneth E.
Maison, Stéphane F.
Polley, Daniel B.
author_sort Jahn, Kelly N.
collection PubMed
description In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity.
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spelling pubmed-91990822022-06-16 Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms Jahn, Kelly N. Hancock, Kenneth E. Maison, Stéphane F. Polley, Daniel B. JASA Express Lett Psychological and Physiological Acoustics In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity. Acoustical Society of America 2022-06 2022-06-13 /pmc/articles/PMC9199082/ /pubmed/35719240 http://dx.doi.org/10.1121/10.0011694 Text en © 2022 Author(s). 0001-4966//2(6)/064403/8 https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Psychological and Physiological Acoustics
Jahn, Kelly N.
Hancock, Kenneth E.
Maison, Stéphane F.
Polley, Daniel B.
Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title_full Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title_fullStr Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title_full_unstemmed Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title_short Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
title_sort estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
topic Psychological and Physiological Acoustics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199082/
https://www.ncbi.nlm.nih.gov/pubmed/35719240
http://dx.doi.org/10.1121/10.0011694
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