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Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Acoustical Society of America
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199082/ https://www.ncbi.nlm.nih.gov/pubmed/35719240 http://dx.doi.org/10.1121/10.0011694 |
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author | Jahn, Kelly N. Hancock, Kenneth E. Maison, Stéphane F. Polley, Daniel B. |
author_facet | Jahn, Kelly N. Hancock, Kenneth E. Maison, Stéphane F. Polley, Daniel B. |
author_sort | Jahn, Kelly N. |
collection | PubMed |
description | In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity. |
format | Online Article Text |
id | pubmed-9199082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Acoustical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-91990822022-06-16 Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms Jahn, Kelly N. Hancock, Kenneth E. Maison, Stéphane F. Polley, Daniel B. JASA Express Lett Psychological and Physiological Acoustics In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity. Acoustical Society of America 2022-06 2022-06-13 /pmc/articles/PMC9199082/ /pubmed/35719240 http://dx.doi.org/10.1121/10.0011694 Text en © 2022 Author(s). 0001-4966//2(6)/064403/8 https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Psychological and Physiological Acoustics Jahn, Kelly N. Hancock, Kenneth E. Maison, Stéphane F. Polley, Daniel B. Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title | Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title_full | Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title_fullStr | Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title_full_unstemmed | Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title_short | Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
title_sort | estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms |
topic | Psychological and Physiological Acoustics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199082/ https://www.ncbi.nlm.nih.gov/pubmed/35719240 http://dx.doi.org/10.1121/10.0011694 |
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