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Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

BACKGROUND: Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. We sugges...

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Detalles Bibliográficos
Autores principales:	Bartlett, Thomas E., Evans, Iona, Jones, Allison, Barrett, James E., Haran, Shaun, Reisel, Daniel, Papaikonomou, Kiriaki, Jones, Louise, Herzog, Chiara, Pashayan, Nora, Simões, Bruno M., Clarke, Robert B., Evans, D. Gareth, Ghezelayagh, Talayeh S., Ponandai-Srinivasan, Sakthivignesh, Boggavarapu, Nageswara R., Lalitkumar, Parameswaran G., Howell, Sacha J., Risques, Rosa Ana, Rådestad, Angelique Flöter, Dubeau, Louis, Gemzell-Danielsson, Kristina, Widschwendter, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199133/ https://www.ncbi.nlm.nih.gov/pubmed/35701800 http://dx.doi.org/10.1186/s13073-022-01063-5

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