Microglial amyloid beta clearance is driven by PIEZO1 channels

BACKGROUND: Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accounting fo...

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Detalles Bibliográficos
Autores principales: Jäntti, Henna, Sitnikova, Valeriia, Ishchenko, Yevheniia, Shakirzyanova, Anastasia, Giudice, Luca, Ugidos, Irene F., Gómez-Budia, Mireia, Korvenlaita, Nea, Ohtonen, Sohvi, Belaya, Irina, Fazaludeen, Feroze, Mikhailov, Nikita, Gotkiewicz, Maria, Ketola, Kirsi, Lehtonen, Šárka, Koistinaho, Jari, Kanninen, Katja M., Hernández, Damian, Pébay, Alice, Giugno, Rosalba, Korhonen, Paula, Giniatullin, Rashid, Malm, Tarja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199162/
https://www.ncbi.nlm.nih.gov/pubmed/35706029
http://dx.doi.org/10.1186/s12974-022-02486-y

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