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Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody

We previously demonstrated that increased monoclonal antibody productivity in dihydrofolate reductase (DHFR)-amplified CHO cells correlates with phosphorylated transcription factor-cytomegalovirus (CMV) promoter interactions. In this article, we extend the characterization to include CMV promoter me...

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Detalles Bibliográficos
Autores principales:	Dahodwala, Hussain, Amenyah, Sophia D, Nicoletti, Sarah, Henry, Matthew N, Lees-Murdock, Diane J, Sharfstein, Susan T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199181/ https://www.ncbi.nlm.nih.gov/pubmed/35719211 http://dx.doi.org/10.1093/abt/tbac010

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