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Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199515/ https://www.ncbi.nlm.nih.gov/pubmed/35719152 http://dx.doi.org/10.3389/fnut.2022.848223 |
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author | Li, Chunyu Lin, Junyu Yang, Tianmi Shang, Huifang |
author_facet | Li, Chunyu Lin, Junyu Yang, Tianmi Shang, Huifang |
author_sort | Li, Chunyu |
collection | PubMed |
description | Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in genetically determined green tea intake was significantly associated with slower progression to dementia (OR: 0.87, 95% CI: 0.81–0.94, P: 3.48E−04) after the Bonferroni correction. Meanwhile, higher green tea intake was nominally associated with slower progression to depression, and lower risk of dementia, depression, hyposmia and insomnia at baseline. The results were robust under all sensitivity analyses. These results might facilitate novel therapeutic targets to slow down the progression of PD in clinical trials, and have clinical implications for patients with PD. |
format | Online Article Text |
id | pubmed-9199515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91995152022-06-16 Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study Li, Chunyu Lin, Junyu Yang, Tianmi Shang, Huifang Front Nutr Nutrition Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in genetically determined green tea intake was significantly associated with slower progression to dementia (OR: 0.87, 95% CI: 0.81–0.94, P: 3.48E−04) after the Bonferroni correction. Meanwhile, higher green tea intake was nominally associated with slower progression to depression, and lower risk of dementia, depression, hyposmia and insomnia at baseline. The results were robust under all sensitivity analyses. These results might facilitate novel therapeutic targets to slow down the progression of PD in clinical trials, and have clinical implications for patients with PD. Frontiers Media S.A. 2022-05-26 /pmc/articles/PMC9199515/ /pubmed/35719152 http://dx.doi.org/10.3389/fnut.2022.848223 Text en Copyright © 2022 Li, Lin, Yang and Shang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Li, Chunyu Lin, Junyu Yang, Tianmi Shang, Huifang Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title_full | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title_fullStr | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title_full_unstemmed | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title_short | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
title_sort | green tea intake and parkinson's disease progression: a mendelian randomization study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199515/ https://www.ncbi.nlm.nih.gov/pubmed/35719152 http://dx.doi.org/10.3389/fnut.2022.848223 |
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