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Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study

Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian r...

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Autores principales: Li, Chunyu, Lin, Junyu, Yang, Tianmi, Shang, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199515/
https://www.ncbi.nlm.nih.gov/pubmed/35719152
http://dx.doi.org/10.3389/fnut.2022.848223
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author Li, Chunyu
Lin, Junyu
Yang, Tianmi
Shang, Huifang
author_facet Li, Chunyu
Lin, Junyu
Yang, Tianmi
Shang, Huifang
author_sort Li, Chunyu
collection PubMed
description Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in genetically determined green tea intake was significantly associated with slower progression to dementia (OR: 0.87, 95% CI: 0.81–0.94, P: 3.48E−04) after the Bonferroni correction. Meanwhile, higher green tea intake was nominally associated with slower progression to depression, and lower risk of dementia, depression, hyposmia and insomnia at baseline. The results were robust under all sensitivity analyses. These results might facilitate novel therapeutic targets to slow down the progression of PD in clinical trials, and have clinical implications for patients with PD.
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spelling pubmed-91995152022-06-16 Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study Li, Chunyu Lin, Junyu Yang, Tianmi Shang, Huifang Front Nutr Nutrition Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in genetically determined green tea intake was significantly associated with slower progression to dementia (OR: 0.87, 95% CI: 0.81–0.94, P: 3.48E−04) after the Bonferroni correction. Meanwhile, higher green tea intake was nominally associated with slower progression to depression, and lower risk of dementia, depression, hyposmia and insomnia at baseline. The results were robust under all sensitivity analyses. These results might facilitate novel therapeutic targets to slow down the progression of PD in clinical trials, and have clinical implications for patients with PD. Frontiers Media S.A. 2022-05-26 /pmc/articles/PMC9199515/ /pubmed/35719152 http://dx.doi.org/10.3389/fnut.2022.848223 Text en Copyright © 2022 Li, Lin, Yang and Shang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Li, Chunyu
Lin, Junyu
Yang, Tianmi
Shang, Huifang
Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title_full Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title_fullStr Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title_full_unstemmed Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title_short Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study
title_sort green tea intake and parkinson's disease progression: a mendelian randomization study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199515/
https://www.ncbi.nlm.nih.gov/pubmed/35719152
http://dx.doi.org/10.3389/fnut.2022.848223
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