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Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States

Great progress has been made in specifically identifying the central neural circuits (CNCs) of the core body temperature (Tcore), sleep-wakefulness states (SWs), and general anesthesia states (GAs), mainly utilizing optogenetic or chemogenetic manipulations. We summarize the neuronal populations and...

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Autores principales: Wu, Jiayi, Liu, Daiqiang, Li, Jiayan, Sun, Jia, Huang, Yujie, Zhang, Shuang, Gao, Shaojie, Mei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199556/
https://www.ncbi.nlm.nih.gov/pubmed/33632102
http://dx.doi.org/10.2174/1570159X19666210225152728
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author Wu, Jiayi
Liu, Daiqiang
Li, Jiayan
Sun, Jia
Huang, Yujie
Zhang, Shuang
Gao, Shaojie
Mei, Wei
author_facet Wu, Jiayi
Liu, Daiqiang
Li, Jiayan
Sun, Jia
Huang, Yujie
Zhang, Shuang
Gao, Shaojie
Mei, Wei
author_sort Wu, Jiayi
collection PubMed
description Great progress has been made in specifically identifying the central neural circuits (CNCs) of the core body temperature (Tcore), sleep-wakefulness states (SWs), and general anesthesia states (GAs), mainly utilizing optogenetic or chemogenetic manipulations. We summarize the neuronal populations and neural pathways of these three CNCs, which gives evidence for the orchestration within these three CNCs, and the integrative regulation of these three CNCs by different environmental light signals. We also outline some transient receptor potential (TRP) channels that function in the CNCs-Tcore and are modulated by some general anesthetics, which makes TRP channels possible targets for addressing the general-anesthetics-induced-hypothermia (GAIH). We suggest this review will provide new orientations for further consummating these CNCs and elucidating the central mechanisms of GAIH.
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spelling pubmed-91995562022-07-10 Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States Wu, Jiayi Liu, Daiqiang Li, Jiayan Sun, Jia Huang, Yujie Zhang, Shuang Gao, Shaojie Mei, Wei Curr Neuropharmacol Neurology Great progress has been made in specifically identifying the central neural circuits (CNCs) of the core body temperature (Tcore), sleep-wakefulness states (SWs), and general anesthesia states (GAs), mainly utilizing optogenetic or chemogenetic manipulations. We summarize the neuronal populations and neural pathways of these three CNCs, which gives evidence for the orchestration within these three CNCs, and the integrative regulation of these three CNCs by different environmental light signals. We also outline some transient receptor potential (TRP) channels that function in the CNCs-Tcore and are modulated by some general anesthetics, which makes TRP channels possible targets for addressing the general-anesthetics-induced-hypothermia (GAIH). We suggest this review will provide new orientations for further consummating these CNCs and elucidating the central mechanisms of GAIH. Bentham Science Publishers 2022-01-10 2022-01-10 /pmc/articles/PMC9199556/ /pubmed/33632102 http://dx.doi.org/10.2174/1570159X19666210225152728 Text en © 2022 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Neurology
Wu, Jiayi
Liu, Daiqiang
Li, Jiayan
Sun, Jia
Huang, Yujie
Zhang, Shuang
Gao, Shaojie
Mei, Wei
Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title_full Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title_fullStr Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title_full_unstemmed Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title_short Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States
title_sort central neural circuits orchestrating thermogenesis, sleep-wakefulness states and general anesthesia states
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199556/
https://www.ncbi.nlm.nih.gov/pubmed/33632102
http://dx.doi.org/10.2174/1570159X19666210225152728
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