The impact of splenectomy on human lipid metabolism

BACKGROUND: Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. METHODS: The d...

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Detalles Bibliográficos
Autores principales: Gunes, Orgun, Turgut, Emre, Bag, Yusuf Murat, Gundoğan, Ersin, Gunes, Ajda, Sumer, Fatih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Academia 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199581/
https://www.ncbi.nlm.nih.gov/pubmed/35756571
http://dx.doi.org/10.48101/ujms.v127.8500
Descripción
Sumario:BACKGROUND: Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. METHODS: The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study. RESULTS: Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL. CONCLUSION: We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.

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