Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes

Hepatic encephalopathy (HE) is a serious neurocognitive complication of liver dysfunction, often associated with elevated plasma ammonia. Ornithine phenylacetate (OP), a potent ammonia scavenger, is being evaluated for the treatment of acute/overt HE. The pharmacokinetics and pharmacodynamics of OP...

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Detalles Bibliográficos
Autores principales: Safadi, Rifaat, Rahimi, Robert S., Thabut, Dominique, Bajaj, Jasmohan S., Ram Bhamidimarri, Kalyan, Pyrsopoulos, Nikolaos, Potthoff, Amy, Bukofzer, Stan, Wang, Laurene, Jamil, Khurram, Devarakonda, Krishna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199870/
https://www.ncbi.nlm.nih.gov/pubmed/35238476
http://dx.doi.org/10.1111/cts.13257

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