Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics

PDE4B (phosphodiesterase‐4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic leukemia (ALL) relapse, as this gene modulates sensitivity of glucocorticoids used...

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Autores principales: Moreira, Rennan Garcias, Saraiva‐Duarte, Julia Maria, Pereira, Alexandre Costa, Sosa‐Macias, Martha, Galaviz‐Hernandez, Carlos, Santolalla, Meddly Lesley, Magalhães, Wagner C. S., Zolini, Camila, Leal, Thiago Peixoto, Balázs, Zsolt, Llerena, Adrián, Gilman, Robert H., Mill, José Geraldo, Borda, Victor, Guio, Heinner, O’Connor, Timothy D., Tarazona‐Santos, Eduardo, Rodrigues‐Soares, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199872/
https://www.ncbi.nlm.nih.gov/pubmed/35266293
http://dx.doi.org/10.1111/cts.13266

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