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A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects

This study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization in healthy subjects. This was a two‐part phase I study (an...

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Detalles Bibliográficos
Autores principales: Ucpinar, Sibel, Darpo, Borje, Neale, Ann, Nunn, Philip, Shu, Jin, Chu, Katherine A., Kavanagh, Marianne, Xue, Hongqi, Phiasivongsa, Pasit, Thomas, Dolca, Smith, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199881/
https://www.ncbi.nlm.nih.gov/pubmed/35301810
http://dx.doi.org/10.1111/cts.13271

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