Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subjects who received oral doses of cyclosporin A (CysA; 20 and 75 mg)...

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Detalles Bibliográficos
Autores principales: Mochizuki, Tatsuki, Aoki, Yasunori, Yoshikado, Takashi, Yoshida, Kenta, Lai, Yurong, Hirabayashi, Hideki, Yamaura, Yoshiyuki, Rockich, Kevin, Taskar, Kunal, Takashima, Tadayuki, Chu, Xiaoyan, Zamek‐Gliszczynski, Maciej J., Mao, Jialin, Maeda, Kazuya, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199885/
https://www.ncbi.nlm.nih.gov/pubmed/35421902
http://dx.doi.org/10.1111/cts.13272

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