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Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids

A series of new paclitaxel-benzoxazoles hybrids were designed based on both the molecular docking mode of beta-tubulin with paclitaxel derivatives (7a and 7g), and the activity-structure relationship of C-13 side chain in paclitaxel. Palladium-catalyzed direct Csp(2)–H arylation of benzoxazoles with...

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Detalles Bibliográficos
Autores principales:	Jiang, Ting, Cao, Ya-Nan, Xu, Jin-Bu, Gao, Feng, Zheng, Ling-Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200075/ https://www.ncbi.nlm.nih.gov/pubmed/35705688 http://dx.doi.org/10.1038/s41598-022-14172-3

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