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HYPK promotes the activity of the N(α)-acetyltransferase A complex to determine proteostasis of nonAc-X(2)/N-degron–containing proteins

In humans, the Huntingtin yeast partner K (HYPK) binds to the ribosome-associated N(α)-acetyltransferase A (NatA) complex that acetylates ~40% of the proteome in humans and Arabidopsis thaliana. However, the relevance of HsHYPK for determining the human N-acetylome is unclear. Here, we identify the...

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Detalles Bibliográficos
Autores principales:	Miklánková, Pavlína, Linster, Eric, Boyer, Jean-Baptiste, Weidenhausen, Jonas, Mueller, Johannes, Armbruster, Laura, Lapouge, Karine, De La Torre, Carolina, Bienvenut, Willy, Sticht, Carsten, Mann, Matthias, Meinnel, Thierry, Sinning, Irmgard, Giglione, Carmela, Hell, Rüdiger, Wirtz, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200280/ https://www.ncbi.nlm.nih.gov/pubmed/35704578 http://dx.doi.org/10.1126/sciadv.abn6153

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