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Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant

Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated electronics, complex artificial intelligence–assisted s...

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Autores principales: Zhao, Haijie, Xue, Shuai, Hussherr, Marie-Didiée, Teixeira, Ana Palma, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200281/
https://www.ncbi.nlm.nih.gov/pubmed/35704573
http://dx.doi.org/10.1126/sciadv.abm4389
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author Zhao, Haijie
Xue, Shuai
Hussherr, Marie-Didiée
Teixeira, Ana Palma
Fussenegger, Martin
author_facet Zhao, Haijie
Xue, Shuai
Hussherr, Marie-Didiée
Teixeira, Ana Palma
Fussenegger, Martin
author_sort Zhao, Haijie
collection PubMed
description Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated electronics, complex artificial intelligence–assisted software, and external energy supplies for power and control. Here, we describe a self-sufficient subcutaneous push button–controlled cellular implant powered simply by repeated gentle finger pressure exerted on the overlying skin. Pushing the button causes transient percutaneous deformation of the implant’s embedded piezoelectric membrane, which produces sufficient low-voltage energy inside a semi-permeable platinum-coated cell chamber to mediate rapid release of a biopharmaceutical from engineered electro-sensitive human cells. Release is fine-tuned by varying the frequency and duration of finger-pressing stimulation. As proof of concept, we show that finger-pressure activation of the subcutaneous implant can restore normoglycemia in a mouse model of type 1 diabetes. Self-sufficient push-button devices may provide a new level of convenience for patients to control their cell-based therapies.
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spelling pubmed-92002812022-06-27 Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant Zhao, Haijie Xue, Shuai Hussherr, Marie-Didiée Teixeira, Ana Palma Fussenegger, Martin Sci Adv Physical and Materials Sciences Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated electronics, complex artificial intelligence–assisted software, and external energy supplies for power and control. Here, we describe a self-sufficient subcutaneous push button–controlled cellular implant powered simply by repeated gentle finger pressure exerted on the overlying skin. Pushing the button causes transient percutaneous deformation of the implant’s embedded piezoelectric membrane, which produces sufficient low-voltage energy inside a semi-permeable platinum-coated cell chamber to mediate rapid release of a biopharmaceutical from engineered electro-sensitive human cells. Release is fine-tuned by varying the frequency and duration of finger-pressing stimulation. As proof of concept, we show that finger-pressure activation of the subcutaneous implant can restore normoglycemia in a mouse model of type 1 diabetes. Self-sufficient push-button devices may provide a new level of convenience for patients to control their cell-based therapies. American Association for the Advancement of Science 2022-06-15 /pmc/articles/PMC9200281/ /pubmed/35704573 http://dx.doi.org/10.1126/sciadv.abm4389 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Zhao, Haijie
Xue, Shuai
Hussherr, Marie-Didiée
Teixeira, Ana Palma
Fussenegger, Martin
Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title_full Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title_fullStr Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title_full_unstemmed Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title_short Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
title_sort autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200281/
https://www.ncbi.nlm.nih.gov/pubmed/35704573
http://dx.doi.org/10.1126/sciadv.abm4389
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