Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

Assessing the role of the WT1 transcription factor (WT1) during early gonad differentiation and its impact on adult sex development has been difficult due to the complete gonadal agenesis and embryonic lethality exhibited by Wt1KO mouse models. Here, we generated Wt1(LoxP/GFP);Wt1(Cre) mice, the fir...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres-Cano, Alejo, Portella-Fortuny, Rosa, Müller-Sánchez, Claudia, Porras-Marfil, Sonia, Ramiro-Pareta, Marina, Chau, You-Ying, Reina, Manuel, Soriano, Francesc X., Martínez-Estrada, Ofelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200307/
https://www.ncbi.nlm.nih.gov/pubmed/35704566
http://dx.doi.org/10.1371/journal.pgen.1010240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200307/
https://www.ncbi.nlm.nih.gov/pubmed/35704566
http://dx.doi.org/10.1371/journal.pgen.1010240

Ejemplares similares