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Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer’s disease outside of the APOE region

Recent meta-analyses combining direct genome-wide association studies (GWAS) with those of family history (GWAX) have indicated very low SNP heritability of Alzheimer’s disease (AD). These low estimates may call into question the prospects of continued progress in genetic discovery for AD within the...

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Detalles Bibliográficos
Autores principales:	de la Fuente, Javier, Grotzinger, Andrew D., Marioni, Riccardo E., Nivard, Michel G., Tucker-Drob, Elliot M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200312/ https://www.ncbi.nlm.nih.gov/pubmed/35658006 http://dx.doi.org/10.1371/journal.pgen.1010208

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