Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types

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Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, pancreatic, and prostate. In these cancers, BRCA1/2 alterations and genomic scar signatures are useful indic...

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Detalles Bibliográficos
Autores principales: Takamatsu, Shiro, Brown, J.B., Yamaguchi, Ken, Hamanishi, Junzo, Yamanoi, Koji, Takaya, Hisamitsu, Kaneyasu, Tomoko, Mori, Seiichi, Mandai, Masaki, Matsumura, Noriomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200383/
https://www.ncbi.nlm.nih.gov/pubmed/35613413
http://dx.doi.org/10.1200/PO.22.00085
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