Cargando…

Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures

Biliary tract cancers (BTCs) are aggressive cancers that carry a poor prognosis. An enhanced understanding of the immune landscape of anatomically and molecularly defined subsets of BTC may improve patient selection for immunotherapy and inform immune-based combination treatment strategies. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mody, Kabir, Jain, Prerna, El-Refai, Sherif M., Azad, Nilofer S., Zabransky, Daniel J., Baretti, Marina, Shroff, Rachna T., Kelley, R. Katie, El-Khouiery, Anthony B., Hockenberry, Adam J., Lau, Denise, Lesinski, Gregory B., Yarchoan, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2022
Materias:	ORIGINAL REPORTS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200391/ https://www.ncbi.nlm.nih.gov/pubmed/35675577 http://dx.doi.org/10.1200/PO.21.00510

Ejemplares similares

Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers
por: Mizrahi, Jonathan D, et al.
Publicado: (2020)

The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma
por: Shroff, Rachna T, et al.
Publicado: (2017)

The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma
por: Shroff, Rachna T, et al.
Publicado: (2018)

MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity
por: Yarchoan, Mark, et al.
Publicado: (2019)

Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer
por: Baretti, Marina, et al.
Publicado: (2022)

Epidemiologic patterns of biliary tract cancer in the United States: 2001–2015
por: Koshiol, Jill, et al.
Publicado: (2022)

Development, Practice Patterns, and Early Clinical Outcomes of a Multidisciplinary Liver Cancer Clinic
por: Jia, Angela Y., et al.
Publicado: (2021)

Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection
por: Delitto, Daniel, et al.
Publicado: (2021)

Real-World Analysis of Treatment Patterns, Healthcare Utilization, Costs, and Mortality Among People with Biliary Tract Cancers in the USA
por: Healey, Marcus J., et al.
Publicado: (2022)

Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life: A Single Center Analysis
por: Gupta, Amol, et al.
Publicado: (2023)

HER2/neu-directed therapy for biliary tract cancer
por: Javle, Milind, et al.
Publicado: (2015)

A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancer
por: Baretti, Marina, et al.
Publicado: (2023)

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors
por: Ahn, Daniel H., et al.
Publicado: (2015)

Impact of the COVID-19 Pandemic on Liver Cancer Staging at a Multidisciplinary Liver Cancer Clinic
por: Li, Daniel, et al.
Publicado: (2022)

Computational Investigation of the Changing Patterns of Subtype Specific NMDA Receptor Activation during Physiological Glutamatergic Neurotransmission
por: Singh, Pallab, et al.
Publicado: (2011)

What is the gender representation in authorship in later phase systemic clinical trials in biliary tract cancer (BTC)? - a retrospective review of the published literature
por: McNamara, Mairéad G, et al.
Publicado: (2022)

Immune Checkpoint Inhibition and the Prevalence of Autoimmune Disorders Among Patients With Lung and Renal Cancer
por: El-Refai, Sherif M, et al.
Publicado: (2017)

Editorial: Elimination of biliary atresia
por: Kotb, Magd Ahmed, et al.
Publicado: (2023)

Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease
por: Ware, Michael B., et al.
Publicado: (2020)

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets
por: Lau, David K., et al.
Publicado: (2019)

Current Understanding in the Clinical Characteristics and Molecular Mechanisms in Different Subtypes of Biliary Atresia
por: He, Lin, et al.
Publicado: (2022)

Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer
por: Ware, Michael Brandon, et al.
Publicado: (2020)

Anesthetic management for parturients with neurological disorders
por: El-Refai, Nesrine Abd El-Rahman
Publicado: (2013)

Multiple Hepatic Hydatid Cysts With Cysto-Biliary Communication and Broncho-Biliary Fistula: A Pediatric Case Report
por: Yahya, El Harras, et al.
Publicado: (2023)

A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype
por: Baretti, Marina, et al.
Publicado: (2021)

Cholangiocarcinoma: a review of the literature and future directions in therapy
por: Halder, Ritika, et al.
Publicado: (2022)

Role of intraoperative cholangiography for detecting residual stones after biliary pancreatitis: still useful? A retrospective study
por: Abdelaal, Abdelrahman, et al.
Publicado: (2017)

Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors
por: Chen, Krista Y., et al.
Publicado: (2022)

Evaluation of Clinical Outcomes in Children with Intrahepatic Cholestasis Postpartial External Biliary Diversion: A Single-Center Experience
por: Nasr El-Din, Hadeer Mohamed, et al.
Publicado: (2023)

Prevalence of Plaque-Induced Gingivitis in a Sample of the Adult Egyptian Population
por: Mostafa, Basma, et al.
Publicado: (2018)

Congenital aflatoxicosis, mal-detoxification genomics & ontogeny trigger immune-mediated Kotb disease biliary atresia variant: SANRA compliant review
por: Kotb, Magd A., et al.
Publicado: (2022)

Salvage Ipilimumab plus Nivolumab after Anti-PD-1/PD-L1 Therapy in Advanced Hepatocellular Carcinoma
por: Alden, Stephanie L., et al.
Publicado: (2023)

A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence
por: Heumann, Thatcher R., et al.
Publicado: (2022)

Bioinformatics analysis identifies heparan sulfate proteoglycans acting as different progress subtypes of biliary atresia
por: Ding, Zequan, et al.
Publicado: (2023)

Phase 2 trial of bintrafusp alfa as second-line therapy for patients with locally advanced/metastatic biliary tract cancers
por: Yoo, Changhoon, et al.
Publicado: (2023)

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing
por: Patel, Kalpesh, et al.
Publicado: (2012)

Proteomics as a Tool for Biomarker Discovery
por: Kohn, Elise C., et al.
Publicado: (2007)

An unusual case of phenotype switch between AML FAB subtypes
por: Das, Animesh, et al.
Publicado: (2015)

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer
por: Yarchoan, Mark, et al.
Publicado: (2017)

Oligoclonal immunoglobulin repertoire in biliary remnants of biliary atresia
por: Taylor, Sarah A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_v3ps5rihbhafq009194u7k0rpk