GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to derive from epithelial failure, particularly that...

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Detalles Bibliográficos
Autores principales: Fernandez, Rafael Jesus, Gardner, Zachary JG, Slovik, Katherine J, Liberti, Derek C, Estep, Katrina N, Yang, Wenli, Chen, Qijun, Santini, Garrett T, Perez, Javier V, Root, Sarah, Bhatia, Ranvir, Tobias, John W, Babu, Apoorva, Morley, Michael P, Frank, David B, Morrisey, Edward E, Lengner, Christopher J, Johnson, F Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Stem Cells and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200405/
https://www.ncbi.nlm.nih.gov/pubmed/35559731
http://dx.doi.org/10.7554/eLife.64430

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