Cell types of origin of the cell-free transcriptome

Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RN...

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Autores principales: Vorperian, Sevahn K., Moufarrej, Mira N., Quake, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200634/
https://www.ncbi.nlm.nih.gov/pubmed/35132263
http://dx.doi.org/10.1038/s41587-021-01188-9
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author Vorperian, Sevahn K.
Moufarrej, Mira N.
Quake, Stephen R.
author_facet Vorperian, Sevahn K.
Moufarrej, Mira N.
Quake, Stephen R.
author_sort Vorperian, Sevahn K.
collection PubMed
description Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.
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spelling pubmed-92006342022-06-17 Cell types of origin of the cell-free transcriptome Vorperian, Sevahn K. Moufarrej, Mira N. Quake, Stephen R. Nat Biotechnol Brief Communication Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases. Nature Publishing Group US 2022-02-07 2022 /pmc/articles/PMC9200634/ /pubmed/35132263 http://dx.doi.org/10.1038/s41587-021-01188-9 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Vorperian, Sevahn K.
Moufarrej, Mira N.
Quake, Stephen R.
Cell types of origin of the cell-free transcriptome
title Cell types of origin of the cell-free transcriptome
title_full Cell types of origin of the cell-free transcriptome
title_fullStr Cell types of origin of the cell-free transcriptome
title_full_unstemmed Cell types of origin of the cell-free transcriptome
title_short Cell types of origin of the cell-free transcriptome
title_sort cell types of origin of the cell-free transcriptome
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200634/
https://www.ncbi.nlm.nih.gov/pubmed/35132263
http://dx.doi.org/10.1038/s41587-021-01188-9
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