Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report

We present the case of a 24-year-old Caucasian man, who developed a scaly erythematous skin rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer; Pfizer, New York, NY, USA) and proved positive for Epstein-Barr virus (EBV) reactivatio...

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Autores principales: Herzum, Astrid, Trave, Ilaria, D’Agostino, Federica, Burlando, Martina, Cozzani, Emanuele, Parodi, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2022
Materias:
COVID-19 Special
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200649/
https://www.ncbi.nlm.nih.gov/pubmed/35799871
http://dx.doi.org/10.7774/cevr.2022.11.2.222
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author Herzum, Astrid
Trave, Ilaria
D’Agostino, Federica
Burlando, Martina
Cozzani, Emanuele
Parodi, Aurora
author_facet Herzum, Astrid
Trave, Ilaria
D’Agostino, Federica
Burlando, Martina
Cozzani, Emanuele
Parodi, Aurora
author_sort Herzum, Astrid
collection PubMed
description We present the case of a 24-year-old Caucasian man, who developed a scaly erythematous skin rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer; Pfizer, New York, NY, USA) and proved positive for Epstein-Barr virus (EBV) reactivation. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines have been associated with an up-regulated T helper type 1-cell response, possibly favoring an immune system imbalance. Also, EBV reactivation has been postulated after COVID-19 vaccination, but only in the immunosuppressed. Noteworthy we report the first case of EBV viral reactivation associated with cutaneous manifestations in an immunocompetent patient after the COVID-19 vaccine.
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spelling pubmed-92006492022-07-06 Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report Herzum, Astrid Trave, Ilaria D’Agostino, Federica Burlando, Martina Cozzani, Emanuele Parodi, Aurora Clin Exp Vaccine Res COVID-19 Special We present the case of a 24-year-old Caucasian man, who developed a scaly erythematous skin rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer; Pfizer, New York, NY, USA) and proved positive for Epstein-Barr virus (EBV) reactivation. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines have been associated with an up-regulated T helper type 1-cell response, possibly favoring an immune system imbalance. Also, EBV reactivation has been postulated after COVID-19 vaccination, but only in the immunosuppressed. Noteworthy we report the first case of EBV viral reactivation associated with cutaneous manifestations in an immunocompetent patient after the COVID-19 vaccine. The Korean Vaccine Society 2022-05 2022-05-31 /pmc/articles/PMC9200649/ /pubmed/35799871 http://dx.doi.org/10.7774/cevr.2022.11.2.222 Text en © Korean Vaccine Society. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle COVID-19 Special
Herzum, Astrid
Trave, Ilaria
D’Agostino, Federica
Burlando, Martina
Cozzani, Emanuele
Parodi, Aurora
Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title_full Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title_fullStr Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title_full_unstemmed Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title_short Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
title_sort epstein-barr virus reactivation after covid-19 vaccination in a young immunocompetent man: a case report
topic COVID-19 Special
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200649/
https://www.ncbi.nlm.nih.gov/pubmed/35799871
http://dx.doi.org/10.7774/cevr.2022.11.2.222
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