Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase

Cancers disrupt host homeostasis in various manners but the identity of host factors underlying such disruption remains largely unknown. Here we show that nicotinamide-N-methyltransferase (NNMT) is a host factor that mediates metabolic dysfunction in the livers of cancer-bearing mice. Multiple solid...

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Detalles Bibliográficos
Autores principales: Mizuno, Rin, Hojo, Hiroaki, Takahashi, Masatomo, Kashio, Soshiro, Enya, Sora, Nakao, Motonao, Konishi, Riyo, Yoda, Mayuko, Harata, Ayano, Hamanishi, Junzo, Kawamoto, Hiroshi, Mandai, Masaki, Suzuki, Yutaka, Miura, Masayuki, Bamba, Takeshi, Izumi, Yoshihiro, Kawaoka, Shinpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200709/
https://www.ncbi.nlm.nih.gov/pubmed/35705545
http://dx.doi.org/10.1038/s41467-022-30926-z

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