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Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Placental function and dysfunction differ by sex but the mechanisms are unknown. Here we show that sex differences in polyamine metabolism are associated with escape from X chromosome inactivation of the gene encoding spermine synthase (SMS). Female placental trophoblasts demonstrate biallelic SMS e...

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Detalles Bibliográficos
Autores principales:	Aye, Irving L. M. H., Gong, Sungsam, Avellino, Giulia, Barbagallo, Roberta, Gaccioli, Francesca, Jenkins, Benjamin J., Koulman, Albert, Murray, Andrew J., Stephen Charnock-Jones, D., Smith, Gordon C. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200719/ https://www.ncbi.nlm.nih.gov/pubmed/35705689 http://dx.doi.org/10.1038/s42003-022-03530-6

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