The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays a...

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Autores principales: Li, Sha, Ren, Chutong, Gong, Yi, Ye, Fei, Tang, Yulong, Xu, Jiangyue, Guo, Can, Huang, Jiangsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200986/
https://www.ncbi.nlm.nih.gov/pubmed/35721746
http://dx.doi.org/10.3389/fendo.2022.872527
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author Li, Sha
Ren, Chutong
Gong, Yi
Ye, Fei
Tang, Yulong
Xu, Jiangyue
Guo, Can
Huang, Jiangsheng
author_facet Li, Sha
Ren, Chutong
Gong, Yi
Ye, Fei
Tang, Yulong
Xu, Jiangyue
Guo, Can
Huang, Jiangsheng
author_sort Li, Sha
collection PubMed
description Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC.
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spelling pubmed-92009862022-06-17 The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer Li, Sha Ren, Chutong Gong, Yi Ye, Fei Tang, Yulong Xu, Jiangyue Guo, Can Huang, Jiangsheng Front Endocrinol (Lausanne) Endocrinology Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9200986/ /pubmed/35721746 http://dx.doi.org/10.3389/fendo.2022.872527 Text en Copyright © 2022 Li, Ren, Gong, Ye, Tang, Xu, Guo and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Sha
Ren, Chutong
Gong, Yi
Ye, Fei
Tang, Yulong
Xu, Jiangyue
Guo, Can
Huang, Jiangsheng
The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title_full The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title_fullStr The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title_full_unstemmed The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title_short The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer
title_sort role of thyroglobulin in preoperative and postoperative evaluation of patients with differentiated thyroid cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200986/
https://www.ncbi.nlm.nih.gov/pubmed/35721746
http://dx.doi.org/10.3389/fendo.2022.872527
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