Cargando…
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities w...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201026/ https://www.ncbi.nlm.nih.gov/pubmed/35720281 http://dx.doi.org/10.3389/fimmu.2022.882515 |
_version_ | 1784728196449566720 |
---|---|
author | Dowell, Alexander C. Powell, Annabel A. Davis, Chris Scott, Sam Logan, Nicola Willett, Brian J. Bruton, Rachel Ayodele, Morenike Jinks, Elizabeth Gunn, Juliet Spalkova, Eliska Sylla, Panagiota Nicol, Samantha M. Zuo, Jianmin Ireland, Georgina Okike, Ifeanyichukwu Baawuah, Frances Beckmann, Joanne Ahmad, Shazaad Garstang, Joanna Brent, Andrew J. Brent, Bernadette White, Marie Collins, Aedin Davis, Francesca Lim, Ming Cohen, Jonathan Kenny, Julia Linley, Ezra Poh, John Amirthalingam, Gayatri Brown, Kevin Ramsay, Mary E. Azad, Rafaq Wright, John Waiblinger, Dagmar Moss, Paul Ladhani, Shamez N. |
author_facet | Dowell, Alexander C. Powell, Annabel A. Davis, Chris Scott, Sam Logan, Nicola Willett, Brian J. Bruton, Rachel Ayodele, Morenike Jinks, Elizabeth Gunn, Juliet Spalkova, Eliska Sylla, Panagiota Nicol, Samantha M. Zuo, Jianmin Ireland, Georgina Okike, Ifeanyichukwu Baawuah, Frances Beckmann, Joanne Ahmad, Shazaad Garstang, Joanna Brent, Andrew J. Brent, Bernadette White, Marie Collins, Aedin Davis, Francesca Lim, Ming Cohen, Jonathan Kenny, Julia Linley, Ezra Poh, John Amirthalingam, Gayatri Brown, Kevin Ramsay, Mary E. Azad, Rafaq Wright, John Waiblinger, Dagmar Moss, Paul Ladhani, Shamez N. |
author_sort | Dowell, Alexander C. |
collection | PubMed |
description | Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities who received COVID-19 vaccination with either ChAdOx1 (n=6) or an mRNA vaccine (mRNA-1273, n=8, BNT162b2, n=1). Strong immune responses were observed after vaccination and antibody levels and neutralisation titres were both higher after two doses. Both measures were also higher after mRNA vaccination and were further enhanced by prior natural infection where one vaccine dose was sufficient to generate peak antibody response. Robust T-cell responses were generated after dual vaccination and were also higher following mRNA vaccination. Early T-cells were characterised by a dominant effector-memory CD4+ T-cell population with a type-1 cytokine signature with additional production of IL-10. Antibody levels were well-maintained for at least 3 months after vaccination and 3 of 4 donors showed measurable neutralisation titres against the Omicron variant. T-cell responses also remained robust, with generation of a central/stem cell memory pool and showed strong reactivity against Omicron spike. These data demonstrate that COVID-19 vaccines display strong immunogenicity in adolescents and that dual vaccination, or single vaccination following prior infection, generate higher immune responses than seen after natural infection and develop activity against Omicron. Initial evidence suggests that mRNA vaccination elicits stronger immune responses than adenoviral delivery, although the latter is also higher than seen in adult populations. COVID-19 vaccines are therefore highly immunogenic in high-risk adolescents and dual vaccination might be able to provide relative protection against the Omicron variant that is currently globally dominant. |
format | Online Article Text |
id | pubmed-9201026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92010262022-06-17 mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 Dowell, Alexander C. Powell, Annabel A. Davis, Chris Scott, Sam Logan, Nicola Willett, Brian J. Bruton, Rachel Ayodele, Morenike Jinks, Elizabeth Gunn, Juliet Spalkova, Eliska Sylla, Panagiota Nicol, Samantha M. Zuo, Jianmin Ireland, Georgina Okike, Ifeanyichukwu Baawuah, Frances Beckmann, Joanne Ahmad, Shazaad Garstang, Joanna Brent, Andrew J. Brent, Bernadette White, Marie Collins, Aedin Davis, Francesca Lim, Ming Cohen, Jonathan Kenny, Julia Linley, Ezra Poh, John Amirthalingam, Gayatri Brown, Kevin Ramsay, Mary E. Azad, Rafaq Wright, John Waiblinger, Dagmar Moss, Paul Ladhani, Shamez N. Front Immunol Immunology Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities who received COVID-19 vaccination with either ChAdOx1 (n=6) or an mRNA vaccine (mRNA-1273, n=8, BNT162b2, n=1). Strong immune responses were observed after vaccination and antibody levels and neutralisation titres were both higher after two doses. Both measures were also higher after mRNA vaccination and were further enhanced by prior natural infection where one vaccine dose was sufficient to generate peak antibody response. Robust T-cell responses were generated after dual vaccination and were also higher following mRNA vaccination. Early T-cells were characterised by a dominant effector-memory CD4+ T-cell population with a type-1 cytokine signature with additional production of IL-10. Antibody levels were well-maintained for at least 3 months after vaccination and 3 of 4 donors showed measurable neutralisation titres against the Omicron variant. T-cell responses also remained robust, with generation of a central/stem cell memory pool and showed strong reactivity against Omicron spike. These data demonstrate that COVID-19 vaccines display strong immunogenicity in adolescents and that dual vaccination, or single vaccination following prior infection, generate higher immune responses than seen after natural infection and develop activity against Omicron. Initial evidence suggests that mRNA vaccination elicits stronger immune responses than adenoviral delivery, although the latter is also higher than seen in adult populations. COVID-19 vaccines are therefore highly immunogenic in high-risk adolescents and dual vaccination might be able to provide relative protection against the Omicron variant that is currently globally dominant. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201026/ /pubmed/35720281 http://dx.doi.org/10.3389/fimmu.2022.882515 Text en Copyright © 2022 Dowell, Powell, Davis, Scott, Logan, Willett, Bruton, Ayodele, Jinks, Gunn, Spalkova, Sylla, Nicol, Zuo, Ireland, Okike, Baawuah, Beckmann, Ahmad, Garstang, Brent, Brent, White, Collins, Davis, Lim, Cohen, Kenny, Linley, Poh, Amirthalingam, Brown, Ramsay, Azad, Wright, Waiblinger, Moss and Ladhani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dowell, Alexander C. Powell, Annabel A. Davis, Chris Scott, Sam Logan, Nicola Willett, Brian J. Bruton, Rachel Ayodele, Morenike Jinks, Elizabeth Gunn, Juliet Spalkova, Eliska Sylla, Panagiota Nicol, Samantha M. Zuo, Jianmin Ireland, Georgina Okike, Ifeanyichukwu Baawuah, Frances Beckmann, Joanne Ahmad, Shazaad Garstang, Joanna Brent, Andrew J. Brent, Bernadette White, Marie Collins, Aedin Davis, Francesca Lim, Ming Cohen, Jonathan Kenny, Julia Linley, Ezra Poh, John Amirthalingam, Gayatri Brown, Kevin Ramsay, Mary E. Azad, Rafaq Wright, John Waiblinger, Dagmar Moss, Paul Ladhani, Shamez N. mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title | mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title_full | mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title_fullStr | mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title_full_unstemmed | mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title_short | mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 |
title_sort | mrna or chad0x1 covid-19 vaccination of adolescents induces robust antibody and cellular responses with continued recognition of omicron following mrna-1273 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201026/ https://www.ncbi.nlm.nih.gov/pubmed/35720281 http://dx.doi.org/10.3389/fimmu.2022.882515 |
work_keys_str_mv | AT dowellalexanderc mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT powellannabela mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT davischris mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT scottsam mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT logannicola mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT willettbrianj mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT brutonrachel mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT ayodelemorenike mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT jinkselizabeth mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT gunnjuliet mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT spalkovaeliska mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT syllapanagiota mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT nicolsamantham mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT zuojianmin mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT irelandgeorgina mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT okikeifeanyichukwu mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT baawuahfrances mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT beckmannjoanne mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT ahmadshazaad mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT garstangjoanna mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT brentandrewj mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT brentbernadette mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT whitemarie mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT collinsaedin mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT davisfrancesca mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT limming mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT cohenjonathan mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT kennyjulia mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT linleyezra mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT pohjohn mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT amirthalingamgayatri mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT brownkevin mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT ramsaymarye mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT azadrafaq mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT wrightjohn mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT waiblingerdagmar mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT mosspaul mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 AT ladhanishamezn mrnaorchad0x1covid19vaccinationofadolescentsinducesrobustantibodyandcellularresponseswithcontinuedrecognitionofomicronfollowingmrna1273 |