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mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273

Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities w...

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Autores principales: Dowell, Alexander C., Powell, Annabel A., Davis, Chris, Scott, Sam, Logan, Nicola, Willett, Brian J., Bruton, Rachel, Ayodele, Morenike, Jinks, Elizabeth, Gunn, Juliet, Spalkova, Eliska, Sylla, Panagiota, Nicol, Samantha M., Zuo, Jianmin, Ireland, Georgina, Okike, Ifeanyichukwu, Baawuah, Frances, Beckmann, Joanne, Ahmad, Shazaad, Garstang, Joanna, Brent, Andrew J., Brent, Bernadette, White, Marie, Collins, Aedin, Davis, Francesca, Lim, Ming, Cohen, Jonathan, Kenny, Julia, Linley, Ezra, Poh, John, Amirthalingam, Gayatri, Brown, Kevin, Ramsay, Mary E., Azad, Rafaq, Wright, John, Waiblinger, Dagmar, Moss, Paul, Ladhani, Shamez N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201026/
https://www.ncbi.nlm.nih.gov/pubmed/35720281
http://dx.doi.org/10.3389/fimmu.2022.882515
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author Dowell, Alexander C.
Powell, Annabel A.
Davis, Chris
Scott, Sam
Logan, Nicola
Willett, Brian J.
Bruton, Rachel
Ayodele, Morenike
Jinks, Elizabeth
Gunn, Juliet
Spalkova, Eliska
Sylla, Panagiota
Nicol, Samantha M.
Zuo, Jianmin
Ireland, Georgina
Okike, Ifeanyichukwu
Baawuah, Frances
Beckmann, Joanne
Ahmad, Shazaad
Garstang, Joanna
Brent, Andrew J.
Brent, Bernadette
White, Marie
Collins, Aedin
Davis, Francesca
Lim, Ming
Cohen, Jonathan
Kenny, Julia
Linley, Ezra
Poh, John
Amirthalingam, Gayatri
Brown, Kevin
Ramsay, Mary E.
Azad, Rafaq
Wright, John
Waiblinger, Dagmar
Moss, Paul
Ladhani, Shamez N.
author_facet Dowell, Alexander C.
Powell, Annabel A.
Davis, Chris
Scott, Sam
Logan, Nicola
Willett, Brian J.
Bruton, Rachel
Ayodele, Morenike
Jinks, Elizabeth
Gunn, Juliet
Spalkova, Eliska
Sylla, Panagiota
Nicol, Samantha M.
Zuo, Jianmin
Ireland, Georgina
Okike, Ifeanyichukwu
Baawuah, Frances
Beckmann, Joanne
Ahmad, Shazaad
Garstang, Joanna
Brent, Andrew J.
Brent, Bernadette
White, Marie
Collins, Aedin
Davis, Francesca
Lim, Ming
Cohen, Jonathan
Kenny, Julia
Linley, Ezra
Poh, John
Amirthalingam, Gayatri
Brown, Kevin
Ramsay, Mary E.
Azad, Rafaq
Wright, John
Waiblinger, Dagmar
Moss, Paul
Ladhani, Shamez N.
author_sort Dowell, Alexander C.
collection PubMed
description Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities who received COVID-19 vaccination with either ChAdOx1 (n=6) or an mRNA vaccine (mRNA-1273, n=8, BNT162b2, n=1). Strong immune responses were observed after vaccination and antibody levels and neutralisation titres were both higher after two doses. Both measures were also higher after mRNA vaccination and were further enhanced by prior natural infection where one vaccine dose was sufficient to generate peak antibody response. Robust T-cell responses were generated after dual vaccination and were also higher following mRNA vaccination. Early T-cells were characterised by a dominant effector-memory CD4+ T-cell population with a type-1 cytokine signature with additional production of IL-10. Antibody levels were well-maintained for at least 3 months after vaccination and 3 of 4 donors showed measurable neutralisation titres against the Omicron variant. T-cell responses also remained robust, with generation of a central/stem cell memory pool and showed strong reactivity against Omicron spike. These data demonstrate that COVID-19 vaccines display strong immunogenicity in adolescents and that dual vaccination, or single vaccination following prior infection, generate higher immune responses than seen after natural infection and develop activity against Omicron. Initial evidence suggests that mRNA vaccination elicits stronger immune responses than adenoviral delivery, although the latter is also higher than seen in adult populations. COVID-19 vaccines are therefore highly immunogenic in high-risk adolescents and dual vaccination might be able to provide relative protection against the Omicron variant that is currently globally dominant.
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spelling pubmed-92010262022-06-17 mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 Dowell, Alexander C. Powell, Annabel A. Davis, Chris Scott, Sam Logan, Nicola Willett, Brian J. Bruton, Rachel Ayodele, Morenike Jinks, Elizabeth Gunn, Juliet Spalkova, Eliska Sylla, Panagiota Nicol, Samantha M. Zuo, Jianmin Ireland, Georgina Okike, Ifeanyichukwu Baawuah, Frances Beckmann, Joanne Ahmad, Shazaad Garstang, Joanna Brent, Andrew J. Brent, Bernadette White, Marie Collins, Aedin Davis, Francesca Lim, Ming Cohen, Jonathan Kenny, Julia Linley, Ezra Poh, John Amirthalingam, Gayatri Brown, Kevin Ramsay, Mary E. Azad, Rafaq Wright, John Waiblinger, Dagmar Moss, Paul Ladhani, Shamez N. Front Immunol Immunology Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellular responses in adolescents with severe neuro-disabilities who received COVID-19 vaccination with either ChAdOx1 (n=6) or an mRNA vaccine (mRNA-1273, n=8, BNT162b2, n=1). Strong immune responses were observed after vaccination and antibody levels and neutralisation titres were both higher after two doses. Both measures were also higher after mRNA vaccination and were further enhanced by prior natural infection where one vaccine dose was sufficient to generate peak antibody response. Robust T-cell responses were generated after dual vaccination and were also higher following mRNA vaccination. Early T-cells were characterised by a dominant effector-memory CD4+ T-cell population with a type-1 cytokine signature with additional production of IL-10. Antibody levels were well-maintained for at least 3 months after vaccination and 3 of 4 donors showed measurable neutralisation titres against the Omicron variant. T-cell responses also remained robust, with generation of a central/stem cell memory pool and showed strong reactivity against Omicron spike. These data demonstrate that COVID-19 vaccines display strong immunogenicity in adolescents and that dual vaccination, or single vaccination following prior infection, generate higher immune responses than seen after natural infection and develop activity against Omicron. Initial evidence suggests that mRNA vaccination elicits stronger immune responses than adenoviral delivery, although the latter is also higher than seen in adult populations. COVID-19 vaccines are therefore highly immunogenic in high-risk adolescents and dual vaccination might be able to provide relative protection against the Omicron variant that is currently globally dominant. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201026/ /pubmed/35720281 http://dx.doi.org/10.3389/fimmu.2022.882515 Text en Copyright © 2022 Dowell, Powell, Davis, Scott, Logan, Willett, Bruton, Ayodele, Jinks, Gunn, Spalkova, Sylla, Nicol, Zuo, Ireland, Okike, Baawuah, Beckmann, Ahmad, Garstang, Brent, Brent, White, Collins, Davis, Lim, Cohen, Kenny, Linley, Poh, Amirthalingam, Brown, Ramsay, Azad, Wright, Waiblinger, Moss and Ladhani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dowell, Alexander C.
Powell, Annabel A.
Davis, Chris
Scott, Sam
Logan, Nicola
Willett, Brian J.
Bruton, Rachel
Ayodele, Morenike
Jinks, Elizabeth
Gunn, Juliet
Spalkova, Eliska
Sylla, Panagiota
Nicol, Samantha M.
Zuo, Jianmin
Ireland, Georgina
Okike, Ifeanyichukwu
Baawuah, Frances
Beckmann, Joanne
Ahmad, Shazaad
Garstang, Joanna
Brent, Andrew J.
Brent, Bernadette
White, Marie
Collins, Aedin
Davis, Francesca
Lim, Ming
Cohen, Jonathan
Kenny, Julia
Linley, Ezra
Poh, John
Amirthalingam, Gayatri
Brown, Kevin
Ramsay, Mary E.
Azad, Rafaq
Wright, John
Waiblinger, Dagmar
Moss, Paul
Ladhani, Shamez N.
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title_full mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title_fullStr mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title_full_unstemmed mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title_short mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
title_sort mrna or chad0x1 covid-19 vaccination of adolescents induces robust antibody and cellular responses with continued recognition of omicron following mrna-1273
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201026/
https://www.ncbi.nlm.nih.gov/pubmed/35720281
http://dx.doi.org/10.3389/fimmu.2022.882515
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