Cargando…

Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study

BACKGROUND: Systemic, low-grade immune–inflammatory activity, together with social and neurocognitive performance deficits are a transdiagnostic trait of people suffering from type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMIs), such as schizophrenia (SZ), major depressive disorder (M...

Descripción completa

Detalles Bibliográficos
Autores principales: Garés-Caballer, Marta, Sánchez-Ortí, Joan Vicent, Correa-Ghisays, Patricia, Balanzá-Martínez, Vicent, Selva-Vera, Gabriel, Vila-Francés, Joan, Magdalena-Benedito, Rafael, San-Martin, Constanza, Victor, Victor M., Escribano-Lopez, Irene, Hernandez-Mijares, Antonio, Vivas-Lalinde, Juliana, Vieta, Eduard, Leza, Juan C., Tabarés-Seisdedos, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201031/
https://www.ncbi.nlm.nih.gov/pubmed/35720107
http://dx.doi.org/10.3389/fneur.2022.883927
_version_ 1784728197932253184
author Garés-Caballer, Marta
Sánchez-Ortí, Joan Vicent
Correa-Ghisays, Patricia
Balanzá-Martínez, Vicent
Selva-Vera, Gabriel
Vila-Francés, Joan
Magdalena-Benedito, Rafael
San-Martin, Constanza
Victor, Victor M.
Escribano-Lopez, Irene
Hernandez-Mijares, Antonio
Vivas-Lalinde, Juliana
Vieta, Eduard
Leza, Juan C.
Tabarés-Seisdedos, Rafael
author_facet Garés-Caballer, Marta
Sánchez-Ortí, Joan Vicent
Correa-Ghisays, Patricia
Balanzá-Martínez, Vicent
Selva-Vera, Gabriel
Vila-Francés, Joan
Magdalena-Benedito, Rafael
San-Martin, Constanza
Victor, Victor M.
Escribano-Lopez, Irene
Hernandez-Mijares, Antonio
Vivas-Lalinde, Juliana
Vieta, Eduard
Leza, Juan C.
Tabarés-Seisdedos, Rafael
author_sort Garés-Caballer, Marta
collection PubMed
description BACKGROUND: Systemic, low-grade immune–inflammatory activity, together with social and neurocognitive performance deficits are a transdiagnostic trait of people suffering from type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMIs), such as schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD). We aimed to determine if immune–inflammatory mediators were significantly altered in people with SMIs or T2DM compared with healthy controls (HC) and whether these biomarkers could help predict their cognition and social functioning 1 year after assessment. METHODS: We performed a prospective, 1-year follow-up cohort study with 165 participants at baseline (TB), including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 HC; and 125 at 1-year follow-up (TY), and determined executive domain (ED), global social functioning score (GSFS), and peripheral blood immune–inflammatory and oxidative stress biomarkers. RESULTS: Participants with SMIs and T2DM showed increased peripheral levels of inflammatory markers, such as interleukin-10 (p < 0.01; η(2)p = 0.07) and tumor necrosis factor-α (p < 0.05; η(2)p = 0.08); and oxidative stress biomarkers, such as reactive oxygen species (ROS) (p < 0.05; η(2)p = 0.07) and mitochondrial ROS (p < 0.01; η(2)p = 0.08). The different combinations of the exposed biomarkers anticipated 46–57.3% of the total ED and 23.8–35.7% of GSFS for the participants with SMIs. LIMITATIONS: Participants' treatment, as usual, was continued without no specific interventions; thus, it was difficult to anticipate substantial changes related to the psychopharmacological pattern. CONCLUSION: People with SMIs show significantly increased levels of peripheral immune–inflammatory biomarkers, which may contribute to the neurocognitive and social deficits observed in SMIs, T2DM, and other diseases with systemic immune–inflammatory activation of chronic development. These parameters could help identify the subset of patients who could benefit from immune–inflammatory modulator strategies to ameliorate their functional outcomes.
format Online
Article
Text
id pubmed-9201031
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92010312022-06-17 Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study Garés-Caballer, Marta Sánchez-Ortí, Joan Vicent Correa-Ghisays, Patricia Balanzá-Martínez, Vicent Selva-Vera, Gabriel Vila-Francés, Joan Magdalena-Benedito, Rafael San-Martin, Constanza Victor, Victor M. Escribano-Lopez, Irene Hernandez-Mijares, Antonio Vivas-Lalinde, Juliana Vieta, Eduard Leza, Juan C. Tabarés-Seisdedos, Rafael Front Neurol Neurology BACKGROUND: Systemic, low-grade immune–inflammatory activity, together with social and neurocognitive performance deficits are a transdiagnostic trait of people suffering from type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMIs), such as schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD). We aimed to determine if immune–inflammatory mediators were significantly altered in people with SMIs or T2DM compared with healthy controls (HC) and whether these biomarkers could help predict their cognition and social functioning 1 year after assessment. METHODS: We performed a prospective, 1-year follow-up cohort study with 165 participants at baseline (TB), including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 HC; and 125 at 1-year follow-up (TY), and determined executive domain (ED), global social functioning score (GSFS), and peripheral blood immune–inflammatory and oxidative stress biomarkers. RESULTS: Participants with SMIs and T2DM showed increased peripheral levels of inflammatory markers, such as interleukin-10 (p < 0.01; η(2)p = 0.07) and tumor necrosis factor-α (p < 0.05; η(2)p = 0.08); and oxidative stress biomarkers, such as reactive oxygen species (ROS) (p < 0.05; η(2)p = 0.07) and mitochondrial ROS (p < 0.01; η(2)p = 0.08). The different combinations of the exposed biomarkers anticipated 46–57.3% of the total ED and 23.8–35.7% of GSFS for the participants with SMIs. LIMITATIONS: Participants' treatment, as usual, was continued without no specific interventions; thus, it was difficult to anticipate substantial changes related to the psychopharmacological pattern. CONCLUSION: People with SMIs show significantly increased levels of peripheral immune–inflammatory biomarkers, which may contribute to the neurocognitive and social deficits observed in SMIs, T2DM, and other diseases with systemic immune–inflammatory activation of chronic development. These parameters could help identify the subset of patients who could benefit from immune–inflammatory modulator strategies to ameliorate their functional outcomes. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201031/ /pubmed/35720107 http://dx.doi.org/10.3389/fneur.2022.883927 Text en Copyright © 2022 Garés-Caballer, Sánchez-Ortí, Correa-Ghisays, Balanzá-Martínez, Selva-Vera, Vila-Francés, Magdalena-Benedito, San-Martin, Victor, Escribano-Lopez, Hernandez-Mijares, Vivas-Lalinde, Vieta, Leza and Tabarés-Seisdedos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Garés-Caballer, Marta
Sánchez-Ortí, Joan Vicent
Correa-Ghisays, Patricia
Balanzá-Martínez, Vicent
Selva-Vera, Gabriel
Vila-Francés, Joan
Magdalena-Benedito, Rafael
San-Martin, Constanza
Victor, Victor M.
Escribano-Lopez, Irene
Hernandez-Mijares, Antonio
Vivas-Lalinde, Juliana
Vieta, Eduard
Leza, Juan C.
Tabarés-Seisdedos, Rafael
Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title_full Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title_fullStr Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title_full_unstemmed Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title_short Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
title_sort immune–inflammatory biomarkers predict cognition and social functioning in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: a 1-year follow-up study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201031/
https://www.ncbi.nlm.nih.gov/pubmed/35720107
http://dx.doi.org/10.3389/fneur.2022.883927
work_keys_str_mv AT garescaballermarta immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT sanchezortijoanvicent immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT correaghisayspatricia immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT balanzamartinezvicent immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT selvaveragabriel immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT vilafrancesjoan immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT magdalenabeneditorafael immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT sanmartinconstanza immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT victorvictorm immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT escribanolopezirene immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT hernandezmijaresantonio immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT vivaslalindejuliana immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT vietaeduard immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT lezajuanc immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy
AT tabaresseisdedosrafael immuneinflammatorybiomarkerspredictcognitionandsocialfunctioninginpatientswithtype2diabetesmellitusmajordepressivedisorderbipolardisorderandschizophreniaa1yearfollowupstudy