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Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase

The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory molecules. Leishmania donovani 24-sterol methyltransferase (LdSMT) is vital for the synthesis of ergosterols, the main c...

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Detalles Bibliográficos
Autores principales:	Sakyi, Patrick O., Broni, Emmanuel, Amewu, Richard K., Miller, Whelton A., Wilson, Michael D., Kwofie, Samuel Kojo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201040/ https://www.ncbi.nlm.nih.gov/pubmed/35719359 http://dx.doi.org/10.3389/fcimb.2022.859981

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