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Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients

BACKGROUND: The Trail Making Test Part-B (TMT-B) is an attention functional test to investigate cognitive dysfunction. It requires the ability to recognize not only numbers but also letters. We analyzed the relationship between brain lesions in stroke patients and their TMT-B performance. METHODS: F...

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Autores principales: Nishimura, Ayako, Sutoko, Stephanie, Kiguchi, Masashi, Atsumori, Hirokazu, Obata, Akiko, Funane, Tsukasa, Kandori, Akihiko, Mizuguchi, Tomohiko, Shimonaga, Koji, Hama, Seiji, Tsuji, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201080/
https://www.ncbi.nlm.nih.gov/pubmed/35720060
http://dx.doi.org/10.3389/fneur.2022.853942
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author Nishimura, Ayako
Sutoko, Stephanie
Kiguchi, Masashi
Atsumori, Hirokazu
Obata, Akiko
Funane, Tsukasa
Kandori, Akihiko
Mizuguchi, Tomohiko
Shimonaga, Koji
Hama, Seiji
Tsuji, Toshio
author_facet Nishimura, Ayako
Sutoko, Stephanie
Kiguchi, Masashi
Atsumori, Hirokazu
Obata, Akiko
Funane, Tsukasa
Kandori, Akihiko
Mizuguchi, Tomohiko
Shimonaga, Koji
Hama, Seiji
Tsuji, Toshio
author_sort Nishimura, Ayako
collection PubMed
description BACKGROUND: The Trail Making Test Part-B (TMT-B) is an attention functional test to investigate cognitive dysfunction. It requires the ability to recognize not only numbers but also letters. We analyzed the relationship between brain lesions in stroke patients and their TMT-B performance. METHODS: From the TMT-B, two parameters (score and completion time) were obtained. The subjects were classified into several relevant groups by their scores and completion times through a data-driven analysis (k-means clustering). The score-classified groups were characterized by low (≤10), moderate (10 < score < 25), and high (25) scores. In terms of the completion time, the subjects were classified into four groups. The lesion degree in the brain was calculated for each of the 116 regions classified by automated anatomical labeling (AAL). For each group, brain sites with a significant difference (corrected p < 0.1) between each of the 116 regions were determined by a Wilcoxon Rank–Sum significant difference test. RESULTS: Lesions at the cuneus and the superior occipital gyrus, which are mostly involved in visual processing, were significant (corrected p < 0.1) in the low-score group. Furthermore, the moderate-score group showed more-severe lesion degrees (corrected p < 0.05) in the regions responsible for the linguistic functions, such as the superior temporal gyrus and the supramarginal gyrus. As for the completion times, lesions in the calcarine, the cuneus, and related regions were significant (corrected p < 0.1) in the fastest group as compared to the slowest group. These regions are also involved in visual processing. CONCLUSION: The TMT-B results revealed that the subjects in the low-score group or the slowest- group mainly had damage in the visual area, whereas the subjects in the moderate-score group mainly had damage in the language area. These results suggest the potential utility of TMT-B performance in the lesion site.
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spelling pubmed-92010802022-06-17 Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients Nishimura, Ayako Sutoko, Stephanie Kiguchi, Masashi Atsumori, Hirokazu Obata, Akiko Funane, Tsukasa Kandori, Akihiko Mizuguchi, Tomohiko Shimonaga, Koji Hama, Seiji Tsuji, Toshio Front Neurol Neurology BACKGROUND: The Trail Making Test Part-B (TMT-B) is an attention functional test to investigate cognitive dysfunction. It requires the ability to recognize not only numbers but also letters. We analyzed the relationship between brain lesions in stroke patients and their TMT-B performance. METHODS: From the TMT-B, two parameters (score and completion time) were obtained. The subjects were classified into several relevant groups by their scores and completion times through a data-driven analysis (k-means clustering). The score-classified groups were characterized by low (≤10), moderate (10 < score < 25), and high (25) scores. In terms of the completion time, the subjects were classified into four groups. The lesion degree in the brain was calculated for each of the 116 regions classified by automated anatomical labeling (AAL). For each group, brain sites with a significant difference (corrected p < 0.1) between each of the 116 regions were determined by a Wilcoxon Rank–Sum significant difference test. RESULTS: Lesions at the cuneus and the superior occipital gyrus, which are mostly involved in visual processing, were significant (corrected p < 0.1) in the low-score group. Furthermore, the moderate-score group showed more-severe lesion degrees (corrected p < 0.05) in the regions responsible for the linguistic functions, such as the superior temporal gyrus and the supramarginal gyrus. As for the completion times, lesions in the calcarine, the cuneus, and related regions were significant (corrected p < 0.1) in the fastest group as compared to the slowest group. These regions are also involved in visual processing. CONCLUSION: The TMT-B results revealed that the subjects in the low-score group or the slowest- group mainly had damage in the visual area, whereas the subjects in the moderate-score group mainly had damage in the language area. These results suggest the potential utility of TMT-B performance in the lesion site. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201080/ /pubmed/35720060 http://dx.doi.org/10.3389/fneur.2022.853942 Text en Copyright © 2022 Nishimura, Sutoko, Kiguchi, Atsumori, Obata, Funane, Kandori, Mizuguchi, Shimonaga, Hama and Tsuji. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Nishimura, Ayako
Sutoko, Stephanie
Kiguchi, Masashi
Atsumori, Hirokazu
Obata, Akiko
Funane, Tsukasa
Kandori, Akihiko
Mizuguchi, Tomohiko
Shimonaga, Koji
Hama, Seiji
Tsuji, Toshio
Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title_full Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title_fullStr Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title_full_unstemmed Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title_short Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
title_sort projection of damaged visual and language regions on low trail making test part-b performance in stroke patients
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201080/
https://www.ncbi.nlm.nih.gov/pubmed/35720060
http://dx.doi.org/10.3389/fneur.2022.853942
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